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Six cases of neurological Lyme disease

Clinicians from Mayo Clinic describe 6 cases of neurological Lyme disease in the journal Open Forum Infectious Diseases. [1] Five of the cases presented with Bannwarth syndrome (BWS), an uncommon manifestation of neurologic Lyme disease.

Can Lyme disease cause dementia?

There have been reports of Borrelia burgdorferi (Bb), the bacterial agent of Lyme disease, triggering primary dementia, such as Alzheimer’s disease. Researchers who examined the records of 1,594 patients with dementia found that 1.25% had a positive intrathecal anti-Borrelia antibody index (AI), specific for neuroborreliosis. They concluded, “Pure Lyme dementia exists and has a good outcome after antibiotics.” 1

Successful treatment for Lyme arthritis after knee surgery

This published case report by Wright and colleagues features what the authors believe is the "first patient with late Borrelia burgdorferi sensu stricto arthritis-related prosthetic joint infection. They suggest "the case highlights how early, prompt diagnosis and adequate antimicrobial therapy may obviate the need for additional aggressive orthopedic surgical intervention."

Can Lyme disease cause jaundice?

Gastrointestinal complications are often seen in Lyme disease. But hyperbilirubinemia, a condition that causes yellow discoloration of the eyes and skin, referred to as jaundice, is a rare manifestation of Lyme disease. Only a handful of cases have been reported in the literature. 

Atypical symptoms of Lyme disease: numbness, paresthesia and abdominal wall weakness

Doctors are beginning to consider Lyme disease as a possible diagnosis in patients who present with unusual symptoms. This case study, published in the New England Journal of Medicine, features a patient with unique manifestations of Lyme disease. Physicians presented the case at neurology grand rounds at Massachusetts General Hospital. [1]

Subacute transverse myelitis caused by Borrelia infection

Lyme neuroborreliosis can manifest as encephalitis or acute/subacute transverse myelitis. Only a handful of subacute transverse myelitis cases have been reported in the literature. In their article, “Subacute transverse myelitis with optic symptoms in neuroborreliosis: a case report,” Opielka et al. describe one of the few cases of subacute transverse myelitis (SaTM) associated with Lyme neuroborreliosis and involving the optic nerve.

Lyme disease infection triggers heart block in young man

Although Lyme carditis is reportedly an infrequent manifestation of Lyme disease, new-onset heart block in young patients is exceptionally rare. And a lack of objective Lyme disease symptoms, such as an erythema migrans rash, can make it challenging to diagnose Lyme carditis in this patient population. But a new tool, developed in 2018, may assist clinicians in identifying possible cases.

Lyme disease and depression case

There has been increasing research linking COVID-19 with the development of neuropsychiatric symptoms, including depression and anxiety. But multiple studies have already found an association between other infections, such as Lyme disease, and the onset of depression.

Atypical findings in Lyme disease makes diagnosing difficult

What happens if there are atypical findings in Lyme disease? A case report by Sharma from the Mayo Clinic in Minnesota describes a 45-year-old man who presented to the emergency room with weakness, chills and oral pseudomembrane (which can be caused by thrush), along with multiple cellulitic-appearing skin lesions.

POTS patients with brain fog have neurocognitive deficits

Individuals with POTS, or postural orthostatic tachycardia syndrome, often complain of cognitive problems, like the inability to focus, difficulty concentrating and forgetfulness. These cognitive symptoms are often referred to as “brain fog” and are commonly seen in POTS patients and other illnesses, including Lyme disease.