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Erythema migrans rash doesn’t always have bull’s eye appearance

An erythema migrans (EM) rash, sometimes referred to as a bull's eye rash, has been considered the signature rash for Lyme disease, leading to a definitive diagnosis. Yet only 1 in 4 erythema migrans rashes present with a bull’s eye appearance.

Single dose doxycycline for treatment of tick bite only prevents Lyme disease rash

In a review entitled “Lyme Disease: Emergency Department Considerations,” Applegren et al. recommend using a one-time, single dose of doxycycline for the prophylactic treatment of a tick bite, [1] despite the fact that there has been only one study exploring the effectiveness of such a limited dosage. The article also neglects to mention that there are doctors who take a different approach and advise against a one-time, single dose. [3]