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How many patients do not meet the CDC criteria for Lyme disease?

In a recent article published in Open Forum Infectious Disease, Kobayashi and colleagues suggest that Lyme disease is often mistakenly diagnosed as causing various illnesses, which has led to the unnecessary use of antibiotics. The authors conducted a retrospective study of patients with possible Lyme disease, who were referred to an infectious disease clinic in Maryland between 2000 and 2013. ¹