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Can’t trust single-dose doxycycline to prevent Lyme disease. Perspective:
Clinicians will often advise patients who have a tick bite to take a single dose of doxycycline to prevent Lyme disease. But this recommendation is based only on findings from one study, which showed that doxycycline prevented patients from developing an EM (or bull’s-eye) rash. It did not demonstrate that the antibiotic stopped patients from developing other manifestations of Lyme disease.
