Lyme disease can be difficult to treat. “One possibility is that persisting organisms are not killed by current Lyme antibiotics,” according to Feng and colleagues from the Department of Molecular Microbiology and Immunology, Johns Hopkins University. As reported in the journal Antibiotics, the authors examined the relative activity of drugs for activities against B. burgdorferi stationary phase cells. 
In a recent review entitled “Lyme Disease: Emergency Department Considerations,” the authors recommend using a one-time, single dose of doxycycline for the prophylactic treatment of a tick bite,  despite the fact that there has been only one study exploring the effectiveness of such a limited dosage. The article also neglects to mention that there are doctors who take a different approach and advise against a one-time, single dose. 
A 30-year-old man with acute Lyme carditis with severe heart block is successfully treated with a temporary pacemaker. “Quite frequently, these young patients are implanted with permanent pacemakers; given lack of knowledge on the transient nature of the cardiac conduction system inflammation,” according to researchers from Ontario, Canada. 
Researchers from the Netherlands have found that a sizeable number of the 1,205 ticks removed from European hedgehogs in urban and suburban areas contain multiple pathogens. In the journal Parasites & Vectors, the authors explain how these European hedgehogs contribute to a “Melting pot of tick-borne zoonoses.” 
The pathogenesis of the Lyme disease bacterium depends on its ability to migrate into human tissue. The virulence of the Lyme disease spirochete could depend on its swimming speed, according to scientists. The authors of “Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium” report that antibiotis in vitro could negatively impact spirochete survival by impeding their swim speed.
Developing a test which can accurately diagnose both early and late-stage Lyme disease has been an ongoing challenge for scientists. Multiple tests are on the market. But a relatively new test, the Nanotrap®, has caught the eye of and garnered financial support from billionaire Bill Gates and his foundation.
Kidney disease induced by Borrelia burgdorferi has been commonly reported in dogs but in the literature there are only a few cases of Lyme disease-associated renal damage in humans. In the February 2017 issue of BMC Nephrology, Florens and colleagues discuss the “unique case of minimal change disease (MCD) associated with chronic Lyme borreliosis that resolved completely after treatment with ceftriaxone and corticosteroids.” 
A research group in the UK described a novel way to determine the risk of tick bites at an outside event. Researchers asked ≈500 participants in a 2-day mountain marathon in Scotland to check for ticks.  Their findings are reported in an Emerging Infectious Diseases article, “Use of Mass-Participation Outdoor Events to Assess Human Exposure to Tickborne Pathogens.”
Thousands of professionals have been working earnestly to understand Lyme disease. The Lyme disease professional community should take credit for the following findings.
You might assume a patient infected with Borrelia miyamotoi, a relapsing fever spirochete, to present with a relapsing fever. However, your assumption would be wrong 48 out of 50 times, according to a case series published in the Annals of Internal Medicine.  The authors found that only 2 out of 50 patients infected with the relapsing spirochete B. miyamotoi actually presented with a relapsing fever.