Atypical presentation of early disseminated Lyme disease

A case report by Kantamaneni and colleagues demonstrates the difficulty in diagnosing patients with atypical presentations of Lyme disease. The authors describe an 80-year-old woman, living in Pennsylvania, who was admitted to the hospital in June 2015 with nonspecific neurological symptoms including fever, confusion, headaches, bilateral lower extremity weakness, and an episode of stool incontinence. [1]


by Daniel J. Cameron, MD MPH

“On presentation to our hospital, the patient continued to complain of severe headaches and was noted to have mild unilateral right-sided facial droop and a diffuse macular rash throughout the body,” explains Kantamaneni in his article, A Case of Early Disseminated Neurological Lyme Disease Followed by Atypical Cutaneous Manifestations.

The woman had a history of hypertension, right-sided thyroidectomy, and stroke. But given that she lived in an endemic region, had an atypical rash and neurologic symptoms, she was started on intravenous ceftriaxone for suspected Lyme disease (LD).

“Our case is peculiar due to the atypical nature of the rash and occurrence of early disseminated neurological disease before the development of diffuse rash.”

Within 24 hours of starting antibiotic therapy, the patient’s headache, fever, lethargy, and neurological manifestations, including a facial droop, resolved. She was treated for 21 days. At a 3-month follow-up, she reported a complete resolution of all of her symptoms.

Lyme serology was ordered. ELISA was positive for IgM antibody, and confirmed by an IgM positive Western blot test (IgM positive for 39, 41; IgG positive for 23 and 41). “Western blot testing was negative for IgG as only two of the 10 bands came back positive, the required being five out of ten,” states Kantamaneni. “Real-time polymerase chain reaction (PCR) of the blood sample tested positive for DNA of Borrelia burgdorferi sensu stricto.”

“Our patient did not have the classic “targetoid” EM rash on initial presentation,” he points out. “Another unique feature was development of the rash after initial neurological manifestations.”

The lack of a bull's eye rash & typical symptoms shouldn't exclude Lyme disease. Click To Tweet

The authors point out that “the suspicion of LD should be very high in endemic areas.” And furthermore, “The lack of the classic bull’s eye appearing rash and typical symptoms should not completely exclude the presence of LD.”

Serologic testing, Kantamaneni states, should be used to support a clinical diagnosis of Lyme disease, not to establish or exclude it. “A positive or negative serologic test simply changes the probability that a patient has been infected with Borrelia burgdorferi.”

If a clinician suspects early disseminated Lyme disease, intravenous antibiotics “should be started immediately without waiting for serology as prompt initiation of antibiotics is paramount to making a quick and a full recovery.”



  1. Kantamaneni, V, Sunder, V, Bilal, M, Vargo, S. Case Reports in Infectious Diseases. April 23, 2017.

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AllisonDr. Daniel CameronLorena MoreyLisa Recent comment authors
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Thank you Dr. Cameron! I am set to see a ILADS doc this coming Wednesday. I know I am not well and symptoms of Lyme are there. I am grateful for you and other doctors like yourself who are providing real help to the public.


I live in NC. In early June, I noticed a weird “mole” on my lower back and was glad I had an upcoming dermatology appointment. About 3-5 days went by, my husband recognized that it was a tick. He pulled it off with tweezers and flushed it. A few days later (June 9), I went to urgent care as there was a very itchy bump with red around it where the tick was removed. I was already on Amox (500 mg/3xs a day for bad tooth abscess) which began June 5 so I just continued that protocol which lasted about… Read more »

Lorena Morey
Lorena Morey

My mother-in-law had a tick bite last Sept./ Oct. time frame. She immediately went to the urgent care, received the usual antibiotic. She has since been tested 3 times for Lyme (all negative) and given the antibiotic treatment a second time. I asked the Dr. to test for other tick diseases, buy the request was ignored. She is experiencing headache, nausea, severe muscle and joint pain, fatigue. She did not have the typical “bulls eye” rash, but recently developed a “scalp infection” and 3 red marks on her neck (under her ear) first on the right side, then the same… Read more »


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