Doctors recognize Lyme disease in a patient with kidney disease

Kidney disease induced by Borrelia burgdorferi has been commonly reported in dogs but in the literature there are only a few cases of Lyme disease-associated renal damage in humans. In the February 2017 issue of BMC Nephrology, Florens and colleagues discuss the “unique case of minimal change disease (MCD) associated with chronic Lyme borreliosis that resolved completely after treatment with ceftriaxone and corticosteroids.” [1]

 

The article, “Chronic Lyme borreliosis associated with minimal change glomerular disease: a case report,” cites four published papers describing kidney damage in Lyme disease patients. The papers consisted of 4 cases of membranoproliferative glomerulonephritis (MPGN), a case of crescentic and IgA-deposit nephropathy, and a case of membranous nephropathy. [1]

In another case, the authors describe a 65-year-old Caucasian woman admitted for an acute edematous syndrome related to a nephrotic syndrome. She had a history of hypertension, dyslipidemia, and elevated blood pressure of 163/89 mmHg. Laboratory data showed hypoalbuminemia (1,2 g/dl), severe proteinuria (7,03 g/24 h) and a recent decrease of renal function (serum creatinine level increase from 0,84 to 1,3 mg/dl). Renal biopsy showed minimal change glomerular disease (MCD). [1]

Lyme disease was diagnosed based on positive serologic tests and a 2-year history of violaceous skin lesions of the right calf. The lesions were diagnosed as Acrodermatitis chronica atrophicans (ACA) by skin biopsy. ACA is a Lyme disease finding in Europe. The patient recalled a history of a tick bite on the same leg 9 years earlier without a rash or arthritis.

“This patient is the first case of minimal change glomerular disease associated with chronic Lyme borreliosis,” according to Florens from Edouard Herriot Hospital, Lyon, France. The patient’s nephrotic syndrome and MCD resolved with a combination of intravenous ceftriaxone and the steroid prednisolone.

The leg lesions and neuropathic pain, which persisted despite 21 days of ceftriaxone and prednisolone, cleared following a second course of 32 days of IV ceftriaxone therapy along with pregabalin.

Based on their investigations, Florens and colleagues recommend further studies of the association between kidney disease and Lyme disease. “The decrease of proteinuria after ceftriaxone therapy observed in our case suggests a link between MCD and Lyme disease,” according to Florens. “T-cells, podocytes and bacterial wall antigens could be involved.”

This case reminds doctors of the need to recognize Lyme disease in patients with kidney disease even if an association has not been established.

 

References:

  1. Florens N, Lemoine S, Guebre-Egziabher F, Valour F, Kanitakis J, Rabeyrin M, Juillard L: Chronic Lyme borreliosis associated with minimal change glomerular disease: a case report. BMC Nephrol 2017, 18(1):51.


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Flow
Flow
5 years ago

5 years ago I had a Hanta nephritis (with 3,08mg/dl max., the creatinine was a few month later at a normal stage (1,04mg/dl) again) In July this year, I was infected with lyme disease. I had two antibiosis but I still feel bad. I have high blood pressure, creatinine of 1,42mg/dl and proteinuria. But my doctors don’t believe that there is connection between the lyme disease and the renal insufficiency – because there is nothing in to find in the literature. I hope, you can change this. I wish you all the best for your further work. If I can support you (e.g. labor results), feel free to contact me.

Kerry Wagner- Lane RPh
Kerry Wagner- Lane RPh
4 years ago
Reply to  Flow

Greetings Flow and all you fellow Lyme Disease sufferers!
My heart is breaking as I read your blogs for th he first time! My name is Kerry and I was born with Lyme Disease in 1955 and have survived an onslaught of autoimmune disorders, like ALS and MS as well as Lyme Carditis and now Lyme Nephritis! I am a Pharmacist since 1991 and had a very successful and lucrative career spaning 5 States! I also raised 4 children but one, my oldest daughter-39yrs died of untreated and undiagnosed Lyme Disease as the blind Western Medicine MDS had misdiagnosed her with ALS!
This willfull denial of the truth and the intentional coverup of the greatest crime against the Western World by The CDC’S, FDA’S, DRUG COMPANIES and Western Medicine is the greatest travesty of this generation!
I need others like you who are willing and able to unite together to fight against the lies and suppression of the Truth by rising up to educate the public concerning the real situation! This is the greatest growing epidemic in the Western Hemisphere!

Carol
Carol
6 years ago

I have had Lyme for about 10+ years my urine infection has got worse. I am in continent. The NHS refuse to treat more than 2 weeks. Nice guidelines talk about chronic rather than re infection. The department of health though it might recognise CE and FDA tests. NHS doctors are still in denial thinking that the illness cures itself. That a resistance occurs. They only treat the condition with oral antibiotics not IV. The Big Tick Project done by Bristol University vet scientists using vets to take radium samples from dogs across the UK has found that they are wide spread. The south east and south coast and Scotland have always been bad. But there is a ridge following the M1. Where it’s high. I believe it’s to do with the increase in technology transmitters following the road. Along with tree’s meant to hide them. The transmitters and wind turbines don’t comply to levels of electromagnetic fields laid down in EMC and EMI law. This is an international law. But governments have been ignoring it for sometime. In the US there is a no complain law brought in in 97. In the U.K. They just removed the legislators in 2002 Radiocommunications Agency and BT’s equivalent was closed to save money. The Mod knew back in the 50/60s that increased levels of electropollution/radiation would kill benifical insects. While leaving Tick, woodlice cockroaches and other similar creatures still alive. The Butterflies and Bees die along with us humans. Governments are more interested in money for licence fees. Industry and the military have told them. But the government think industry and the Mod can solve it. So we die of cancer and possible Lyme Disease. While we are told to eat right and take excersize. Oh and sleep when this stuff goes though our brains. For this they will send us to a psychatrist who will give us a happy pill. Financing both the electronics industry and the pharmaceutical industry. There’s more money in the electronics industry than the pharmaceutical industry. The Lyme vaccine has not been invented for Humans as yet. They keep saying it’s coming soon. Animals are still using Type A OSP whether it really works. Or is just a contaminate in the food chain. As animals don’t show pain. Their herd members would attack them. A vet can’t tell if a dog has Lyme. The farmer just excepts… Read more »

Deanna Stazinski
Deanna Stazinski
6 years ago

My son is 8. He had terrible kidney pain a few hours ago. When he was almost 3 yrs old he had severe bladder pain that led him to be hospitalized. Doctors thought it was a brain tumor, extreme pain disorder, Fabry disease…after months in a Chicago hospital, 4 weeks at Mayo, they all gave up. It was lyme disease. He has been on a variety of antibiotics for the past 4 years. I started to take him off about a month ago. Now this pain. I don’t know what to do. I am glad you are puplishing studies about this. I am not surprised Lyme and/or coninfections are causing kidney and bladder pain. My son’s urologist’s do not believe it, but I do.

Joe Walton
6 years ago

My 16 year old daughter who is extremely active in sports has been tested positive for Lonestar Tick Disease. Over the past couple years since her diagnosis, she has recently been experiencing extreme fatigue, been light headed, hot/sweaty, and urinates frequently. We took her to a Cardiologist where she tested positive in a tilt test. The doctor gave her Fludocortisone to try to put a hormone in her body to make her body retain water better but it has not helped. She also was prescribed metoprolol. She has been taking it for two weeks with no improvement. Since there is not a lot on the disease, I was wondering if you knew of any similar cases or if her symptoms could even have anything to do with it.

Sandy Ellis
Sandy Ellis
6 years ago

I have stage three kidney disease and was positive for lyme disease. I did antibiotics and was tested after treatment with two different labs and still tested positive . I also had colon cancer in 2009.

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