Dr. Daniel Cameron: Inside Lyme Podcast
A confused woman with Anaplasmosis and Babesia infection
Welcome to an Inside Lyme case study. I find that the best way to get to know Lyme disease is through reviewing actual cases. I will be discussing a 78-year-old confused woman with an Anaplasmosis and Babesia infection.
A 78-year-old woman was evaluated in an emergency room with fever, chills, lethargy, fatigue, and confusion. Her maximum temperature was 100.6° F.
Her blood tests were quite abnormal. She had severe anemia, low white blood count, and low platelet count.
• Anemia (dropped from 10.5 g/dL to a low of 8 g/dL)
• Leukopenia (dropped from 5.0 × 10 9 /L to 2.6 × 10 9 /L)
• Thrombocytopenia (dropped to 39 × 10 9 /L)
The doctor initially considered sepsis. Sepsis is a potentially life-threatening illness triggered by an infection. The body’s immune response can be so strong that the body can attack itself and can lead to organ damage and death.
Anaplasmosis and Babesia infection
She also had multiple tick bites.
The doctors were able to identify the parasite that causes a Babesia infection in the woman’s red blood cells under the microscope. Babesia is a disease transmitted by the same tick that carries Lyme disease.
The doctors prescribed a combination of atovaquone and azithromycin for her Babesia infection. These medications are marketed under the names Mepron and Zithromax in the US.
The doctors were also concerned that the woman might suffer from another tick-borne illness called Anaplasmosis because of her low white blood count and low platelet count. Anaplasmosis had previously been called Ehrlichia.
The combination of atovaquone and azithromycin is not effective for Anaplasmosis. The doctors added doxycycline to the woman’s treatment.
The laboratory test confirmed that she had, in fact, an anaplasmosis and babesia infection. The IgM tests were positive for both conditions consistent with early infection.
The woman’s cognitive function improved dramatically following two weeks of treatment, according to the authors.
What can we learn from these cases?
- Tick-borne diseases can lead to confusion in the elderly.
- An individual with a tick-borne infection can be confused with sepsis.
What questions do these cases raise?
- How many elderly with tick-borne illnesses are confused?
- What if the parasites associated with the Babesia infection had not been seen in the red blood cells under the microscope? Would the woman have been diagnosed in a timely manner for Babesia?
- What might have happened to the woman if the doctors had not considered Anaplasmosis?
- What might have happened to the woman if the doctors had stopped treatment if the tests were negative?
- What is the long-term outcome for the elderly with tick-borne infections? Could the woman’s short term confusion described in this case lead to long term confusion?
Treating Tick-Borne Disease In My Practice
In my practice, each individual requires a careful assessment. That is why I order a broad range of blood tests for other illnesses in addition to tick-borne infections. I also arrange consultations with specialists as needed.
Many patients are complex, as highlighted in this Inside Lyme Podcast series.
We need more doctors with skills diagnosing and treating Lyme disease in the elderly. We hope that a professional evaluating the elderly can use this case to remind them to look for Lyme disease and co-infections and treat accordingly.
Inside Lyme Podcast Series
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- Paparone P, Paparone PW. Variable clinical presentations of babesiosis. Nurse Pract. 2018;43(10):48-54.
07/26/2020 (6:57 am)
It’s been said the standard Rx used for Babesia is 2X750 mg atovaquone and 500 mg Azithromycin. Yet, some specialists with the disease insist this is simply too low and virtually no patient has been cured with this routine.Moreover, some are recommending Coartem as being more effective than the 2 drugs mentioned,considerably so.
Dr. Daniel Cameron
07/26/2020 (9:28 am)
I have not come to the same conclusion for many of my patients. I often find Malarone, a prescription that contains 250 twice a day of atovaquone. I have not advised Coartem. Not everyone agrees.
Katherine Murray Leisure MD
05/01/2020 (12:34 pm)
Very common scenario. If also bitten by dog Dermacentor ticks, the patients might have three (3) tick borne infections, adding Rickettsias to the cocktail. Rickettsioses might add transient, reversible strokes or head CVA’s in these young and old tick-infected people. Many great imitator diseases occur in tick-endemic areas beyond Lyme and the borrelioses. Thank you, Dr Cameron!!!
05/01/2020 (10:49 am)
Thank you, Dr. Cameron, for your dedication and consistently excellent commentary! Because of your pioneering efforts with these horrific tick-borne diseases, the medical community is slowly becoming more intelligent about our country’s virtual plague of Lyme and its co-infections! Please keep on fighting the ignorance that is still much too prevalent! Thank you!
Dr. Daniel Cameron
05/01/2020 (11:33 am)