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Lyme Science Blog

Should I Worry About Herxing? My Answer for Lyme Patients

Should I Worry About Herxing? My Answer for Lyme Patients

One of the biggest concerns Lyme disease patients have when beginning treatment is whether or not they will have a herxing response. In fact, it’s one of the most common questions I hear in my practice: “What if I Herx?” A Herxheimer reaction (or “Herx”) is a temporary flare of symptoms that can occur when […]

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Lyme Disease and Joint Pain: Is It Debris—or a Missed Persistent Infection?

Lyme Disease and Joint Pain: Is It Debris—or a Missed Persistent Infection?

New research into Lyme arthritis (joint pain due to an infection with Borrelia burgdorferi) is challenging long-standing assumptions about what causes persistent symptoms after treatment. For years, many clinicians believed that when patients continued to experience swollen joints, even after treatment with antibiotics, the inflammation was simply due to an overactive immune system. The body’s

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Babesia doesn’t just affect immunocompromised Lyme disease patients

She wasn’t immunocompromised. So why was she still sick months after Lyme treatment?That was the question we kept coming back to. She’d been told Babesia wouldn’t be a problem—unless she had a weakened immune system. She didn’t. But she was still dealing with fatigue, air hunger, night sweats, and brain fog long after her Lyme

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Can one doxycycline dose really stop Lyme disease?

Can one doxycycline dose really stop Lyme disease?

When a patient walks into my office after a tick bite, they often ask: “Isn’t one dose of doxycycline enough to prevent Lyme disease?” That belief traces back to a 2001 study that has, unfortunately, shaped Lyme disease treatment guidelines. But what most people don’t realize is that the study only found that the single

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My Lyme Disease Patient Got Worse on Antibiotics—Until We Adjusted the Dose

He was ready to quit treatment. The antibiotics were making him feel worse, not better—nausea, fatigue, and a sense that his body was shutting down. He told me, “Doc, I don’t think I can keep doing this.” I knew we needed a new approach—but not necessarily a new medication. Instead, I asked:What if we adjusted

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Can you have neurologic Lyme disease even if your spinal tap is normal?

🧠 When a Patient Hears “Spinal Tap,” They Often Ask: “Do I really need one just to check for Lyme disease?” It’s a reasonable question. A spinal tap—more formally, a lumbar puncture—is invasive, uncomfortable, and not without risks. But the conversation around spinal taps and Lyme disease is often oversimplified. So today, let’s unpack the

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My doctor wants to give me steroids—will that make Lyme worse?

My doctor wants to give me steroids—will that make Lyme disease worse?

It’s a fair concern. Steroids are widely used to reduce inflammation, but they come with significant risks when used during an active infection—especially Lyme disease. The conversation is often oversimplified or brushed aside. So today, let’s break it down—in the form of a clinical dialogue. A Clinical Dialogue on Steroids in Lyme Disease Cameron: One

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Why I Treated Him for Lyme Even When His Test Was Negative

Why I Treated Him for Lyme—Even When His Test Was Negative

Patients Deserve an Explanation One of the most common—and most important—questions I hear from patients is: “If my Lyme test is negative, why are you still treating me?” It’s a fair question. And if you’re asking it, you deserve a clear and compassionate answer. The truth is, when it comes to Lyme disease, test results

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Unexpected Relief from Allodynia: Lyme Disease Treatment Worked!

Allodynia is a neurological condition where non-painful stimuli—like a breeze, the pressure of clothing, or even light touch—cause pain. It’s often associated with central sensitization, where the brain and spinal cord become overly responsive to nerve signals. But sometimes, the trigger is more than just misfiring nerves. Sometimes, it’s caused by an infection, such as

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Could Piperacillin Be the Lyme Breakthrough We Need?

Could Piperacillin Be the Lyme Disease Breakthrough We Need?

A recent study published in Science Translational Medicine by researchers at Northwestern University has generated cautious optimism in the Lyme disease community. The study found that an older antibiotic—piperacillin—was able to clear Borrelia burgdorferi, the bacteria that causes Lyme disease, in mice at doses 100 times lower than doxycycline. This is noteworthy. Doxycycline has long

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