Lyme Science Blog

Persistent Infection in Lyme Disease Persistent infection in Lyme disease is one proposed explanation for why some patients continue to experience fatigue, pain, cognitive dysfunction, sleep disruption, and autonomic symptoms after standard treatment. In clinical practice, this possibility remains important because some persistent symptom patterns are difficult to explain by a single post-infectious mechanism alone. […]

Persistent Lyme Disease: Why Symptoms Continue After Treatment Persistent Lyme disease describes ongoing symptoms that continue after Lyme disease treatment or fail to fully resolve over time. Patients may experience fatigue, brain fog, pain, dizziness, sleep disruption, or reduced function long after the initial infection. For a broader overview of symptom patterns, see our Lyme

Lyme Flare vs Relapse: What’s the Difference? Patients with Lyme disease often ask the same question when symptoms suddenly worsen: Is this a flare—or a relapse? These symptom patterns are part of the broader spectrum of Lyme disease symptoms, which often fluctuate over time. The distinction matters, but it is not always straightforward. Symptoms in

Neuroinflammation in Lyme Disease Neuroinflammation in Lyme disease may help explain why symptoms such as brain fog, fatigue, and slowed thinking can persist—even when standard tests are normal and initial treatment has been completed. Many patients describe difficulty concentrating, memory problems, and reduced mental clarity that interfere with daily life. These symptoms are increasingly understood

Why Early Lyme Disease Symptoms Are Often Missed Early Lyme disease symptoms—often referred to as early Lyme symptoms—are often missed because they can be subtle, nonspecific, and easily mistaken for more common conditions. Patients may experience fatigue, headaches, mild cognitive changes, or generalized discomfort—symptoms that do not immediately suggest a tick-borne illness. Because these early

Why Do Lyme Symptoms Last So Long? Many patients expect Lyme disease symptoms to resolve quickly after treatment. Yet some individuals continue to experience fatigue, joint pain, cognitive difficulties, or neurologic symptoms for months or even years. Understanding why Lyme symptoms last so long requires looking beyond the initial infection and examining the biological processes

Lyme Disease Specialist: Daniel Cameron, MD This page is part of a broader guide to Lyme disease, including symptoms, testing, mechanisms, and recovery. Dr. Daniel Cameron is a Lyme disease specialist and past president of the International Lyme and Associated Diseases Society (ILADS), with decades of experience diagnosing and treating patients with complex tick-borne illnesses,