Lyme Science Blog

When Pain Persists Beyond Infection Some patients with Lyme disease experience pain that spreads, fluctuates, or intensifies long after the acute infection has been treated. Symptoms may worsen with stress, sleep disruption, or physical exertion and often seem disproportionate to findings on examination or testing. When conventional explanations fall short, it becomes necessary to consider […]

Exhausted despite sleeping in Lyme disease Many patients with Lyme disease describe the same experience: they sleep through the night yet wake feeling depleted. This article focuses on biologic fatigue and impaired recovery, not sleep duration alone. Feeling exhausted despite sleeping often reflects what clinicians describe as non-restorative sleep, a state in which sleep occurs

Many patients with Lyme disease describe a frustrating and often frightening experience: they can no longer think the way they used to. Concentration is harder. Words feel just out of reach. Tasks that once felt automatic now require intense effort. This constellation of symptoms is commonly referred to as brain fog in Lyme disease. While

Pediatric Lyme screening is rarely part of routine medical care, even in regions where tick exposure is common. When early Lyme disease is not recognized, diagnosis and treatment are often delayed until symptoms become more complex and disruptive. In children, missed or delayed pediatric Lyme screening can have lasting consequences, affecting learning, behavior, and long-term

The Early Warning Signs of a Lyme Flare That Patients Know Before It Hits You’re not “sick” yet.But your body knows.You feel the shift — before the symptoms have a name. It might start with a flash of irritability.Or a strange sense of clarity that doesn’t match your day.Then the fatigue rolls in. And you

If your digestion has slowed and nothing seems to help, you’re not alone Constipation is a common and often frustrating symptom in people with Lyme disease. Some patients notice fewer bowel movements. Others experience hard stools, straining, bloating, or a constant sense of incomplete emptying despite adequate hydration and fiber. This symptom is common in

The debate over chronic Lyme vs PTLDS isn’t just about words—it’s about whether patients feel validated or dismissed. Many patients use chronic Lyme disease to describe ongoing fatigue, pain, and brain fog. Some clinicians prefer post-treatment Lyme disease syndrome (PTLDS), a term that sounds more neutral but often feels minimizing. Did You Know? Most patients

Many patients expect Lyme disease to resolve once antibiotic treatment is completed. For some, however, symptoms persist or evolve long after therapy ends. Post-treatment Lyme disease syndrome (PTLDS) is commonly used to describe ongoing fatigue, pain, cognitive dysfunction, and neurologic symptoms that persist long after standard treatment for Lyme disease. For patients, PTLDS is not

Many patients with Lyme disease experience persistent symptoms that are increasingly understood to involve immune dysregulation, even long after the initial infection has been treated. These symptoms are often misunderstood or minimized. Increasingly, they are recognized as reflecting immune dysregulation and neuroinflammation—a state in which immune signaling fails to return fully to baseline and continues