Can Lyme disease cause dementia?

can lyme disease cause dementia

There have been reports of Borrelia burgdorferi (Bb), the bacterial agent of Lyme disease, triggering primary dementia, such as Alzheimer’s disease. Researchers who examined the records of 1,594 patients with dementia found that 1.25% had a positive intrathecal anti-Borrelia antibody index (AI), specific for neuroborreliosis. They concluded, “Pure Lyme dementia exists and has a good outcome after antibiotics.” 1

In a retrospective study, entitled “Secondary dementia due to Lyme neuroborreliosis,” Kristoferitsch and colleagues describe several case reports of patients diagnosed with dementia-like syndromes due to Lyme neuroborreliosis or Lyme disease that help address the question – can lyme disease cause dementia.2

Rapid improvement with antibiotic treatment

The authors’ case report featuring a 76-year-old woman demonstrates how Lyme disease can cause dementia-like symptoms. The patient developed progressive cognitive decline, loss of weight, nausea, gait disturbance and tremor over a 12-month period. She was referred to a neurology clinic for evaluation.

Three months earlier, the woman had been diagnosed with tension headaches and a depressive disorder. Medications, however, did not improve her symptoms.

Further testing revealed bilateral white matter lesions and an old lacunar lesion located at the left striatum. Extensive neurocognitive testing found “a severe decline of attention, memory and executive functions corresponding to subcortical dementia,” the authors write.

“LNB [Lyme neuroborreliosis] was diagnosed when further CSF [cerebral spinal fluid] examinations disclosed a highly elevated Bb-specific-AI indicating local intrathecal Bb-specific antibody synthesis,” Kristoferitsch writes.

After a 3-week course of treatment with ceftriaxone, the woman “recovered rapidly,” the authors write.

“In a telephone call in February 2018 at the age of 82 years, the patient reported no gait problems or cognitive impairment and had just returned from a trip to Cuba,” the authors write.

Woman admitted to psychiatric ward with severe dementia

A 71-year-old woman with rapidly progressing dementia and short periods of altered consciousness was admitted to a psychiatric hospital. Six months earlier, she was having mild forgetfulness.

MRI results, which indicated slight mesiotemporal atrophy, along with neurocognitive testing supported an initial diagnosis of primary dementia.

[bctt tweet=”Dementia-like syndromes can occur as the result of Lyme neuroborreliosis or Lyme disease.” username=”DrDanielCameron”]

“Later, the patient’s daughter reported a tick bite followed by a widespread rash,” the authors write. “Thus, LNB [Lyme neuroborreliosis] was suspected and confirmed by CSF investigations.”

After 2 weeks of antibiotic treatment with ceftriaxone, the woman’s symptoms subsided and her cognition improved.

READ MORE: 80-year-old man with Lyme encephalopathy instead of dementia

At her 5-year follow-up visit, the woman’s “cognition was stable” and memory tests indicated a score above the mean for females her age, “which strongly argued against any dementing process,” the authors write.

In reviewing the literature, Kristoferitsch et al. identified several signs and symptoms that may indicate that Lyme neuroborreliosis (or Lyme disease) is causing dementia in a patient.

Distinguishing features of Lyme-induced dementia

  • Most of the patients or family members did not recall previous tick bites, an EM rash or symptoms of Lyme disease. Therefore, when “EM or other characteristic symptoms of early LB 1–2 years before the onset of dementia may if untreated serve as an indicator for chronic LNB.”
  • Unlike most neurodegenerative dementias, dementia caused by Lyme disease appears to progress rapidly, the authors write.
  • “Weight loss is another symptom observed in LNB [Lyme neuroborreliosis],” the authors explain. “It is also compatible with the diagnosis of AD [Alzheimer’s disease] but when it occurs in chronic LNB, it can be more pronounced, reaching up to 20 kg/year.” Weight loss in patients with Alzheimer’s disease is less prominent, the authors explain.
  • Headache, nausea, malaise and vomiting are typically not symptoms of degenerative dementias, the authors explain. But, “might be associated with secondary dementia and thus also with chronic LNB [Lyme neuroborreliosis].”
  • Gait disturbances at the onset or early in the disease which was observed in all cases of this study, makes the diagnosis of a probable AD [Alzheimer’s disease] uncertain or unlikely.”

Additionally, “In most patients, improvement of symptoms was reported already within a few days of antibiotic treatment,” Kristoferitsch writes.

Can lyme disease cause dementia?

The authors stress the importance of recognizing Lyme-induced dementia-like syndromes.

“It is essential to be aware of this manifestation of Lyme neuroborreliosis, because early antibiotic treatment will prevent permanent sequelae that may occur throughout the further course of the untreated disease,” the authors conclude.

  1. Blanc F, Philippi N, Cretin B, et al. Lyme neuroborreliosis and dementia. J Alzheimers Dis. 2014;41(4):1087-1093. doi:10.3233/JAD-130446
  2. Kristoferitsch W, Aboulenein-Djamshidian F, Jecel J, et al. Secondary dementia due to Lyme neuroborreliosis. Wien Klin Wochenschr. 2018;130(15-16):468-478. doi:10.1007/s00508-018-1361-9

5 Replies to "Can Lyme disease cause dementia?"

  • Cat
    10/03/2022 (1:46 pm)

    I am 68 and have recently been diagnosed with Black Mold, CAEBV and now Lyme. Triple hitter! I have struggled for the last 30+ years, off and on, with extreme fatigue and body/joint – aches/pain, low grade fever AND brain fog for many years. Always feeling like I am going to get very sick with the flu and then it passes. Looking back I can almost relate the flares to extra stressful times in my life. The brain issues have been getting worse and so now this last diagnosis of Lyme shines a new light. I remember having a blood filled tick on my leg back in my very early teens. Could I have had this in my system all these years and not have known until now? I am praying that treatment will give me back my life and short term memory. The word-loss is the most frustrating part of all of this. I am a walker, I eat organic as much as possible and I am not on any meds accept Armor Thyroid. This article has given me new hope! We will be starting treatment on the Lyme, once we go through the series of anti-fungal for the mold toxins. I am so thankful for the insight!

  • Nancy Ellen Killoran
    08/02/2021 (7:13 am)

    We spent so much money and time traveling to visit Dr. Cameron. On first (initial) visit he gave us so much hope that the memory and brain fog issues were in fact lymes disease and could be treated. Then we paid the cash. The 2nd visit we traveled from Washington DC again and saw him for approximately 3 minutes. It was all a complete waste of time and money and gave hope to a very athletic young man with early onset alzheimers. Just can’t express enough the disappointment and disgust at Dr. Cameron’s practice. The issue with the Lymes treater and bad, inept, cash business was our unfortunate experience.

    • Dr. Daniel Cameron
      08/02/2021 (12:50 pm)

      I am so sorry that the memory and brain fog issues did not turn out to be Lyme disease. There are so few treatments for dementia.

    • Zee Smith
      06/16/2022 (3:06 pm)

      Have you tried Ivermectin? I am hoping that the wide spectrum antibacterial will help my Mother’s memory issues. There has to be some bacteria causing the brain processes. It’s not a normal occurrence.

      • Dr. Daniel Cameron
        06/16/2022 (5:53 pm)

        Ivermectin is a Food and Drug Administration (FDA)-approved antiparasitic drug. Some doctors use ivermectin off label. I have not considered ivermectin a broad spectrum antibiotic.

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