Neurologic Lyme Disease: Bannwarth Syndrome Cases
Neurologic Lyme disease can affect the brain, peripheral nerves, and spinal nerve roots. One manifestation is Bannwarth syndrome, a neurologic condition characterized by painful radiculopathy, neuropathy, facial nerve palsy, motor weakness, and cerebrospinal fluid (CSF) lymphocytic pleocytosis.
Neurologic Lyme disease, also known as Lyme neuroborreliosis, can present with a wide range of neurologic symptoms. Shah and colleagues describe six cases of neurologic Lyme disease, five of which involved peripheral nervous system findings primarily axonal in nature and consistent with Bannwarth syndrome.
Radiculopathy, or inflammation of the spinal nerve roots, can produce severe nerve pain, weakness, and sensory disturbances in patients with neurologic Lyme disease. Three of the cases from this series are summarized below.
What Is Bannwarth Syndrome?
Bannwarth syndrome is a neurologic form of Lyme disease characterized by severe radicular pain, nerve inflammation, and sometimes facial nerve palsy. The syndrome is frequently reported in Europe but may be underrecognized in North America.
61-Year-Old Man With Neurologic Lyme Disease
A 61-year-old man with a history of daily tick exposure presented with progressive back pain, upper torso and extremity paresthesias, right-sided facial droop, and blurry vision in the right eye, writes Shah.
Four weeks earlier he had been treated for an erythema migrans (EM) rash with doxycycline for five days.
Testing revealed positive IgM and IgG antibodies to Borrelia burgdorferi. The patient was diagnosed with neurologic Lyme disease and Bannwarth syndrome.
According to Shah, “the patient demonstrated significant neurologic improvement following four weeks of intravenous ceftriaxone.”
62-Year-Old Woman With Progressive Weakness
A 62-year-old woman presented with subacute onset of lower extremity weakness that progressed over three weeks to flaccid paralysis.
She also experienced radiating low back and abdominal pain accompanied by numbness.
[bctt tweet=”Study describes patients with Lyme disease presenting as Bannwarth syndrome.” username=”DrDanielCameron”]
Diagnostic testing confirmed Bannwarth syndrome and neurologic Lyme disease. Magnetic resonance imaging (MRI) of the spine showed diffuse inflammation of the cauda equina.
Cerebrospinal fluid analysis demonstrated pleocytosis, and a real-time polymerase chain reaction (RT-PCR) assay confirmed Lyme disease infection.
After completing a four-week course of intravenous ceftriaxone, the patient reported improvement in mobility. However, she required extensive assistance for approximately two months following treatment.
29-Year-Old Man With Foot Drop and Radiculopathy
In June 2017, a 29-year-old man developed fever, myalgias, chills, headache, and fatigue. He also reported a transient erythematous rash on his trunk.
Two weeks later he developed right foot drop, Trendelenburg gait, lower extremity radiculopathy, and painful L5–S1 paresthesias. Over the next 10 weeks he lost approximately 15 pounds.
The patient declined a spinal tap. Based on his clinical presentation and positive Lyme disease test results, physicians diagnosed neurologic Lyme disease.
After two weeks of intravenous ceftriaxone, he reported complete resolution of symptoms.
Patterns Observed Across the Case Series
All five patients presented with upper or lower extremity radiculopathy and/or paresthesias. Several additional neurologic findings were observed.
Shah notes that the broader peripheral neuropathy seen in three patients was somewhat atypical. Two patients developed visual disturbances with nerve root enhancement in the cauda equina or lumbar spine, and one patient presented with Lyme disease–associated facial nerve palsy.
The authors conclude that “the constellation of neurological symptoms, particularly when associated with a recent or suspected tick bite in a Lyme disease–endemic region, should prompt clinical evaluation for Lyme neuroborreliosis and assessment for Bannwarth syndrome.”
These cases illustrate how neurologic Lyme disease may present with radiculopathy, neuropathy, and motor weakness, highlighting the importance of recognizing Bannwarth syndrome in patients with suspected tick exposure.
Related Articles:
Chronic neurological Lyme disease or co-morbid conditions?
Neurologic Lyme disease presenting as abdominal pain in 71-year-old patient
References:
- Shah A, O’Horo JC, Wilson JW, Granger D, Theel ES. An unusual cluster of neuroinvasive Lyme disease cases presenting with Bannwarth syndrome in the Midwest United States. Open Forum Infect Dis. 2018;5(1):ofx276.
Dr. Daniel Cameron, MD, MPH
Lyme disease clinician with over 30 years of experience and past president of ILADS.
Symptoms • Testing • Coinfections • Recovery • Pediatric • Prevention
Quote- “… this syndrome may be more common than previously presumed in North America.” YA THINK? That’s why we call it Hold The Mayo! And they are just now figuring this out (or admitting it)? UGH!
Yeah, I had same type symptoms, never recognized for what it was. It actually resolves and relapses. Pretty sure this is VERY common in Lyme.
It bothers me they still.insist on spinal tap when the regular unintrusive blood smear does the same thing…
…but the blood tests are not always positive. Mine were negative but lumbar puncture revealed the antibodies.
Diagnoses around 1988 and treated with in three weeks of a tick bite. I thought I was cured after taking the RX. Forgot about it until two months ago while conversing with some they had told me they have Lyme Disease and I had mentioned that I “had” it. I was told to get a test from my PCP…tested positive 2018 and to Doxicycline for 30 days.
Went for an eye exam and shared an temporary blindness in one eye for 2-3 mins. one summer day, passed out twice (hit my head on sink’s edge on my way down). Past vehicle accidents w/head injuries. Been experiencing migraine for five years straight which began after three car accidents (while sitting still). Past three months eye pain, headaches while asleep that awakes me.
My eye doctor referred me to an opthamologist who then ref. me to a neurologist whom ref. me to a neuro-ophthalmology neuro-ophthalmologist for lumbar puncture to measure spinal fluids, conduct a brain scan for tumors, and to be treated for Psendopapilledema and papilledema to save me from blindness and brain damage.
The right side of my right arm started swelling with pain daily for eight weeks and right hand swelling. Then my left leg began swelling.
Do you think my issues favor Psendopapilledema or pappedilema symptoms? My neuro-ophthalmology appt. is four weeks away.
I have often seen patients with a series of finding where a tick borne illness is a consideration. Your vision is a top priority and is being carefully evaluated. Your migraines, right arm swelling, left leg swelling, head trauma are additional concerns. There may be other issues you have not included in your notes. It would be reasonable to include an evaluation by a doctor familiar with tick borne pathogens.
My symptoms began with strange double vision, and nerve pain in my hands feet, including a burning /stabbing feeling at the bottom of the soles of my feet, all this one time for approximately two weeks. Now I have short term memory loss, inability to concentrate, letter reversal when spelling, extreme anxiety oh, a 40 pound weight loss, a 40 pound weight gain.
I am thinking about being seen by Mayo clinic however I’ve heard negative reviews about them when testing for Lyme disease.
I don’t know what to do because where I live all the Doctors and Hospital Systems I have gone to has dismissed my symptoms for psychiatric. I’m at a loss and want my life back…
Hang in there and keep advocating for yourself. Keep looking for a doc that will listen. My darling daughter had bad symptoms for 3+years that we were told were all in her head. She has been since diagnosed with Lyme and we are finally getting treatment. It took me one day, saying NO, no more telling us there’s nothing wrong with her. Hang in there. Reach out to Lyme community, Facebook has been a good place for me, as her mom. Best of luck!
I was diagnosed with late stage Lyme disease about 5 years ago had a spinal tap and it’s positive all through my cns. Had 2 rounds of oral antibiotics then a pic line , still positive had another pic line . What a horrible experience ended up with cdiff, cold wet feeling through my legs, feeling like my body was turning into stone . Had 5 major surgeries, and broke my femer bone 6 months ago. My body is full of arthritis from head to toe , now I have a torn disc and more arthritis in 2 discs more surgery. Does anyone know if Lyme disease ever goes away. Does anyone have the same symptoms. I’m at the end of my rope. Sometimes live is not worth living, it just gets worse and worse. I’m lost and need help . Thanks for listening to my story. I had someone reread this to correct my mistakes as my brain goes wild with thoughts and forgetting things. .
I feel the same way. I don’t know how much more I can take. I’ve gotten Lyme 3 times and the first in 2002 and the doctor never told me. I got horrible muscle spasms all up my legs and hands and each night have to swallow 8-10 large magnesium pills. 2013 I got small fiber neuropathy and my feet are numb, inflammatory arthritis and dysautonomia. Lost my sense of smell etc. this May I got it again and the neuropathy in my legs increased 10 fold and now my left hand is numb. I also have awful osteoarthritis and this horribly painful psoas tendinopathy. Now can barely walk up a flight of stairs. The abx have made me herx so bad and so nauseous and weak. I had a non-definitive cancer test come back positive twice. I see the oncologist tomorrow and have to drink 2 things of barium for a gi cat scan and my psoas started hurting again. I don’t know how much I can take or what I did to deserve this. My whole life since 2013 has been doctors and research trying to get better but I keep getting worse. The only thing that keeps me going is that I know how many other people are suffering from Lyme disease. I don’t know why the medical establishing it does not recognize this horrific disease and what I can do to a persons body. A woman down the street from me is in a wheelchair permanently from it. I guess I’m not ready to give up hope yet. I wish I could talk to you.
I have not tested positive for Lymes but had two bands on the Western Blot test which they said that means I was exposed to Lymes years ago. I lived in East Hampton . I went through a bout of heart palpitations three years ago , with dizziness , night sweats and fatigue. I have had two spinal taps which were negative and an MRI in NYC that showed nothing . I now am on a walker as without it I fall , my right foot drags. I saw a Lymes specialist in NYC who put me on a 4.5 month treatment of ceftriaxone it stabilized me but no improvement. I stopped that treatment and have gotten worse. Are there any new protocals for the treatment of chronic neurological Lymes? I am 73 and live in Jupiter Florida, i just can’t walk I am not really in pain.
There are other treatments. For example, I have found treatment for Babesia helpful. I also look for other illnesses at the same time. You could call my office at 914 666 4665 with any questions or a telemedicine visit.
I have all of your symptoms as well. Have you figured anything out
Hi Dr,
My name is Chinyere Evulukwu. I have been suffering with debilitating symptoms for four months. It started with panic attacks and derealizazion/dp, then trouble sleeping because of bad headaches and sensations along with feet numbness, back cramps, weakness, frequent urination, dry mouth, floaters, parasthesia. My mom has a weird medical history but she’s smelling things that are not there. My dad also had a weird illness that messed up his lungs and he had to be on oxygen for a while. Now he suffers from weird neurological symptoms and really bad hip arthritis. I’ve been to different doctors and no one has found anything except my low red, hemoglobin, and white blood cells. Also done eeg and mri which showed non specific white matter. I’ve done the basic Lyme test and it came out negative so my pcp doesn’t want to treat me even after I described my symptoms to him. I’m sleeping better now but i have weakness and this weird feeling of depersonalization and derealization. I really don’t know what to do.
I find tick borne testing not as reliable as I would like. I have to include specialists to rule out other causes of illness. I have to use clinical judgment to determine who to treat if the tests are negative. I have seen derealization in Lyme disease patients. They typically have other issues to support the diagnosis. Call my office at 914 666 4665 if you have any questions.
How reliable is a spinal tap for Lyme disease compared to a blood test? At this point I’d do it just to find out if I had it. I feel like my family dr should be telling me this instead of me scrounging around the internet for every morsel of information I come across. Which a lot I forget due to brain fog. I’m at my wits end.
In the Logigian and colleagues study, only one in ten neurologic Lyme disease patients tested positive for Lyme disease by spinal tap. I have had to use clinical judgement.
I had a lumbar puncture and what my doc was looking at as confirmation of Lyme were the presence of oligoclonal bands , multiple bands were present in both my spinal fluid and blood serum which indicates more of an infectious agent, if these oligoclonal bands are found in just the spinal fluid and not in the blood this is more indicative of MS or other diseases. Hope this is helpful
Medicine is not as simple as we thought. Oligoclonal bands can have other causes including Lyme disease.
I am 55 y/o with chronic Lyme disease along with 5 Lyme co-infections (5 different Bartonella). I have had erratic blood pressure and heart rate for years that is very hard to control. My heart rate also goes up on its own without me doing much other than walking to the bathroom. When this happens my BP goes way up too most of the time. I am on 3 different blood pressure medications and one for emergencies. The emergency medicine, Hydralazine, usually works fast and as long as I stay in bed for a couple hours it passes. I have been been to the hospital dozens of times per year and get released after things pass. I am on Corlanor to keep my heart rate low (50s to low 60s) most of the time. I still find my heart rate jumping from 50s to the 120s daily then right back down 5 minutes later then back up and down again most of the day. I have a Fitbit to keep track of my heart rate and it is amazing to see the spikes every day all day even with the Corlanor and a Beta blocker BP pills twice a day. My BP or heart rate can go up independently or together. I have been on multiple high doses of antibiotics at the same time for months at a time and don’t seem to get much benefit other than taking down the Lyme and co-inflections for a short period of time. I seem to have triggers like having a glass of wine or a beer which send my BP up to 240’s over 140s. I am not a heavy drinker and enjoyed a beer or glass of wine out with friends once or twice a week when I could. I also have other side effects like constipation, brain fog, and overheating to name a few. I have had short periods where things went back to normal and I go to the bathroom normal as well as can have a beer or glass of wine. These good times are few and far between the last 4 years and it has been 11 months now straight with constant problems. If I didn’t work from my bed at home for the last 4 years I don’t think I could have worked and now it seems as if I can’t even work from bed at home without constant BP and heart rate issues. My symptoms and condition seem to get even worse with the change of seasons in the fall and cold weather in the winter. I don’t know what to do anymore and need help bad. What do you suggest?
I have had Lyme disease patients with autonomic issues similar to yours. I look again at tick borne infections as well as consult a cardiologist. I also consider POTS.
I had Lyme disease 15 years ago, with muscular pain in legs and knees (mostly on the right). Although antibiotic treatment appeared to have cleared the infection, recently, lower back pain and severe pain along my legs has restarted. The symptoms are identical with what I previously experienced and more worryingly, I seem to be losing muscular strength in my right leg. I’m due for an MRI on my lower spine next week, but I am convinced that the bacteria have been lying dormant for years and are now starting up again.
I would typically add a Lyme disease evaluation if the issues are not resolved. It could also be a new infection.
I have most likely have had Lyme disease for over 15 years , diagnosed August 2019, positive Igenex bands 34,39 and 41. Most likely bitten in western Massachusetts, many symptoms for years, worsening overtime with feet neuropathy, burning feet, extreme muscular skeletal pain and joint pain.
I finally found my way through my neurologist to an excellent infectious disease doc here in Northern California where I live. I did have a lumbar puncture which revealed multiple oligoclonal bands in spinal fluid and serum, this was more confirmation for Lyme , I had brain mri which revealed small white lesions.
I was treated with 30 days IV ceftrioxone through a picc line followed by 4 weeks oral doxycycline 200 mgs, I began to feel better but a few months later it all came back with a vengeance, even more severe pain.
I just began 30 days IV of a 3 cocktail antibiotic of Daptomycin, ceftrioxone by IV and then orally doxycycline 100 mgs twice a day . This combination is based on animal studies of eradicating the persister forms of Borrelia. The doc in charge of these studies is Dr Zhang of John Hopkins research studies on chronic Lyme .
Has anyone here ever been on this triple antibiotic combo or is familiar with dr Zhang??
Hi Suzanne,
How has the 3 cocktail antibiotic of Daptomycin, ceftriaxone, and doxycycline worked for you so far? I’ve been on ceftriaxone and doxycycline, but haven’t started the daptomycin yet.
I have been following the daptomycin research but have not started using it.
Over 2 years ago, I had severe pain in neck and shoulder which was worse at night and ended up sleeping for weeks in a recliner. PCP finally put me on steroids and sent me to a rheumatologist who finally took a Lyme test. I had every band positive! 6 weeks of Doxy, developed neuropathy from head to toe on left side of body. Did 30 days of IV Ceftriaxone and nerve pain and neuropathy kept getting worse. Saw many doctors and finally ended up last week with a neurologist who believes I have nerve damage due to Lyme and also believes there is no cure! I’m on Cymbalta and will increase till tolerated. I’m also on Propanalol for head tremors and also had Botox injections to calm down the muscles/nerves. (possibly Cervical Dystonia) Anyone else have this problem? Has anyone found anything to help with nerve pain and neuropathy?
It sounds as if the neurologist is continuing to try thing. Some neurologists also try IVIG. I have patients who might benefit from a different antibiotic e.g. treatment for Babesia.
Gabapentil works for nerve pain. 300mg 6 a day
I know it’s been some time since anyone replied, but I want to leave my story in case I can be of help or someone can help me because I’m honestly at the end of my rope. I was diagnosed with neurological Lyme summer of 2021 after 2 months of strange & escalating symptoms, from fluctuating heart rate & fatigue to headaches in back of my head, stiff neck, knee & elbow arthritis, insomnia, weakness in arms/shoulders, & seizure/panic-like attacks. Lyme meningitis was suspected, but no confirmation with spinal tap. I was given 6 wks of oral Doxy, & was told within 6 months I should resolve. Most has to a point, but I have developed memory problems, issues retrieving words, & the attacks/weak arms haven’t stopped. In fact, tres still a near-daily experience for me. I’m also still unable to lay down on my back without my heart rate increasing, getting lightheaded, & feeling like I’m driving down a hill too fast.
During these attacks, my arms & hands may go numb/tingly or not at all, but I’m unable to lift them above my belly button (almost like my upper body relaxes too much) & my shoulders ache. I still experience a strange feeling in my chest when the attacks start, almost like we’re driving down a hill too fast, I get at least mildly lightheaded, & I feel tingles in my upper body, which follows with a panic because I know it’s not right or normal… or maybe the panic itself is just part of it. I also feel short of breath without being short of breath. My oxygen, BP, & HR don’t even fluctuate much if at all during this, even though it feels like they do. The only relief I find on my own, strangely, is leaning over a pillow on my chest, like I’m relieving pressure on some sort of nerve. I have also developed some aversion to nearly any medication, herb, or thing in the air that interacts with the nervous system. I can no longer drink caffeine, use most otc meds including multivitamins, or herbs. Anesthetics like Lidocaine at the dentist & otc Azo for bladder pain – all send me into a severe attack. And I mean severe, hours long, rocking in the corner level attacks. I’ve been given Ativan to use in the most emergent of situations, which is honestly the only thing of the many things we’ve tried that calms this down… but I’ve basically been told that my doctors are no longer comfortable prescribing these & I’ve been trying my best to get through this on my own. Which honestly is eating me alive after months of this continuing day after day & to put it lightly, it’s a letdown that I can’t at least be comfortable during all of this.
I’ve also tried several other medications, herbs, breathing techniques- you name it, I’ve done it. Neurology refuses to see me because I already have a Lyme diagnosis & so does ID to my knowledge. I just… I simply can’t find relief & I think another part of me feels a little hopeless when I comb through groups or sites like this with Lyme stories & don’t find anyone with anything near like my experience. I’m starting to wonder if it isn’t permanent nerve damage & how I’m going to keep supporting my family, as I’ve only gotten through to now on sheer determination. As strong as I am, as supportive as my family is, & as understanding as my work is… I can only take so much. As a as I hope no one else suffers through anything similar to my horror story, a little piece of me hopes someone at least knows what’s going on because even my own doctor is at a loss & we’re at a standstill.
Wow.. Bekkah! Sorry your experience has been so frustrating & difficult. I have been dealing with many of your symptoms for decades & being an LD clinical trial victim has left me continually struggling since 1995. My 3 children have been affected too. Ticks & the bacterias they carry have been here on Cape Cod for over 100 years! Good luck.. you may NEED to see a lyme literate doc soon or nothing.. will improve. Take care