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Lyme Science Blog

Understanding Central Sensitization in Lyme Disease

Pain Processing and Central Sensitization in Lyme Disease

Central Sensitization in Lyme Disease: Why Pain Persists Pain that spreads, shifts, or worsens over time may not reflect ongoing infection—it may reflect how the nervous system is processing pain. Central sensitization in Lyme disease can explain why some patients continue to experience pain long after treatment. The pain may move, intensify, or feel out […]

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EXHAUSTED AFTER A FULL NIGHT’S SLEEP

Exhausted Despite Sleeping With Lyme Disease (Why Rest Fails)

Why Am I Exhausted After Sleeping? Lyme Disease and Non-Restorative Sleep Quick Answer: Many patients with Lyme disease feel exhausted even after a full night’s sleep because sleep is not fully restorative. Autonomic dysfunction, inflammation, and disrupted sleep architecture can prevent overnight recovery. Clinical Insight: When patients wake unrefreshed despite adequate sleep duration, the issue

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WHY LYME BRAIN FOG HAPPENS

Brain Fog and Cognitive Dysfunction in Lyme Disease: Symptoms and Causes

Brain Fog and Cognitive Dysfunction in Lyme Disease: Symptoms and Causes Many patients with Lyme disease describe a frustrating and often frightening experience: they can no longer think the way they used to. Brain fog in Lyme disease reflects slowed thinking, poor concentration, and memory problems driven by neurologic and inflammatory changes. Concentration is harder.

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Why Pediatric Lyme Screening Can’t Wait

Why Pediatric Lyme Screening Can’t Wait

When to Test for Lyme Disease in a Child: Pediatric Screening Guide Start here: Pediatric Lyme Disease: Symptoms, Diagnosis, and Challenges When should a child be tested for Lyme disease? Testing should be considered when a child develops unexplained symptoms such as fatigue, headaches, joint pain, behavior changes, or learning difficulties—especially after outdoor exposure in

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Early Warning Signs of a Lyme Flare: Symptoms Patients Notice First

  Early Warning Signs of a Lyme Flare: Symptoms Patients Notice First YOU FEEL IT BEFORE IT HITS? EARLY SIGNS OF A LYME FLARE The early warning signs of a Lyme flare often begin before a full crash. Patients may notice subtle mood changes, strange fatigue, sensory overload, digestive changes, or a sudden sense that

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IBS and Lyme Disease:

Constipation in Lyme Disease: Why Gut Motility Slows

Constipation in Lyme Disease: Why Gut Motility Slows CONSTIPATION THAT WON’T RESPOND? NORMAL TESTS BUT PERSISTENT SYMPTOMS? COULD THIS BE LYME-RELATED DYSFUNCTION? Constipation in Lyme disease is common and often misunderstood—especially when diet, hydration, and routine testing appear normal. “I was doing everything right—but nothing was working.” Quick Answer: Constipation in Lyme disease is often

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Chronic Lyme vs PTLDS: The Debate

Chronic Lyme vs PTLDS: The Debate

Chronic Lyme vs PTLDS: What’s the Difference and Why It Matters The debate over chronic Lyme vs PTLDS isn’t just about terminology—it’s about whether patients feel validated or dismissed. :contentReference[oaicite:0]{index=0} Many patients use chronic Lyme disease to describe ongoing fatigue, pain, and brain fog. Some clinicians prefer post-treatment Lyme disease syndrome (PTLDS), a term that

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Persistent Lyme Disease Symptoms

Persistent Lyme Disease Symptoms: Why You May Still Feel Sick

Persistent Lyme Disease Symptoms: Why You May Still Feel Sick FINISHED TREATMENT? STILL NOT BETTER? WHY DO LYME SYMPTOMS PERSIST? Persistent Lyme disease symptoms can continue after treatment, leaving patients with fatigue, cognitive slowing, pain, and other symptoms that affect daily life. Some patients recover quickly after Lyme disease treatment. Others continue to experience fatigue,

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iMMUNE DYSREGULATION IN LYME DISEASE

Immune Dysregulation in Lyme Disease: Why Symptoms Persist

Immune Dysregulation in Lyme Disease: Why Symptoms Persist Immune dysregulation in Lyme disease may help explain why symptoms such as fatigue, pain, and cognitive changes can persist—even when tests are normal and initial treatment has been completed. Many patients improve—but do not return fully to baseline. This page explains why. Clinical Insight: Persistent symptoms in

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