Don’ t confuse somatic symptoms with depression in early Lyme disease

depression, anxiety

Patients with early Lyme disease appeared to be depressed when evaluated with the Beck Depression Inventory (BDI-II) tool, according to a study by Wormser and colleagues, published in the American Journal of Medicine. [1] But after antibiotic treatment, the patients’ BDI-II scores returned to normal, leading the authors to conclude that these patients, in fact, did not suffer from depression.


The 1-year prospective study included 52 adult Lyme disease patients with erythema migrans (EM) rashes. Their somatic symptoms included fatigue, headache, joint pain, muscle pain, and cognitive complaints.

Individuals with the worst symptoms had the worst BDI-II scores. The BDI-II scale has been used as a screening tool for patients who might benefit from further psychological evaluation for diagnosing depression.

Read: 16-year-old boy with Lyme disease presenting as depression

“There was a good to excellent direct correlation between the BDI-II score and the total number of symptoms,” writes Wormser, “suggesting that the BDI-II scores were reflecting somatic rather than affective depressive symptoms.”

When using the BDI-II assessment tool for patients with Lyme disease, “infection-related somatic symptoms per se need to be considered in the interpretation of results,” the authors conclude.

If depression is suspected, the authors recommend a psychological referral. In fact, at the 6 month visit, one patient in their study was referred for a depression evaluation based on the Beck Depression Inventory.

“The single Lyme disease patient with a score regarded as severe, which was found only at the 6 month visit, was treated by a mental health professional between the 6 and 12 months visits, and improved by the 12 month visit. This patient had a prior history of depression when she was pregnant.”

  1. Wormser GP, Park K, Madison C, et al. Evaluation of Prospectively Followed Adult Patients with Erythema Migrans Using the Beck Depression Inventory Second Edition. Am J Med. 2018.

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4 years ago

Dr Cameron,
A loved one has in the last 7 mos experienced leg cramps, progressing into fasiculations, numbness/tingling, burning, and leg weakness. Depression also. Will see a neurologist soon. Not sure if it is CIPD, MS, or much worse. Read your website and Dr Tedone’s ( where he strongly feels it contributes/causes ALS and many neurodegenerative diseases? Therefore want to get the test for Borrelia infection. You are the expert. Please advise where to go for the most accurate test for Lyme Disease? Is it at iGenex? If it is negative should testing be repeated again? If it’s positive, what are the proper antibiotics and for how long? Have you seen these antibiotics work on neurological symptoms? Please help us with your expertise. Most neurologists we’ve briefly talked to don’t believe there is a link! Lastly, if we would like a phone consultation with you, how do we get in touch with you? Thanks, Joe at

4 years ago

this seems a little confusing. The depression is real but not caused by the infection/co-infection. It is caused by overthinking the future of one’s life and the quality one will have with no absolute answers.