Lyme Science Blog

Why Am I Exhausted After Sleeping? Lyme Disease and Non-Restorative Sleep Quick Answer: Many patients with Lyme disease feel exhausted even after a full night’s sleep because sleep is not fully restorative. Autonomic dysfunction, inflammation, and disrupted sleep architecture can prevent overnight recovery. Clinical Insight: When patients wake unrefreshed despite adequate sleep duration, the issue […]

Brain Fog and Cognitive Dysfunction in Lyme Disease: Symptoms and Causes Many patients with Lyme disease describe a frustrating and often frightening experience: they can no longer think the way they used to. Brain fog in Lyme disease reflects slowed thinking, poor concentration, and memory problems driven by neurologic and inflammatory changes. Concentration is harder.

7 Gut Clues Lyme Disease Might Be Involved Stomach pain. Nausea. Bloating. Sometimes the gut is one of the first systems affected. Normal GI tests do not always mean normal function. An 11-year-old girl had been struggling with stomach aches, poor appetite, and nausea for months. She was missing school, and every gastrointestinal test came

  Early Warning Signs of a Lyme Flare: Symptoms Patients Notice First YOU FEEL IT BEFORE IT HITS? EARLY SIGNS OF A LYME FLARE The early warning signs of a Lyme flare often begin before a full crash. Patients may notice subtle mood changes, strange fatigue, sensory overload, digestive changes, or a sudden sense that

Constipation in Lyme Disease: Why Gut Motility Slows CONSTIPATION THAT WON’T RESPOND? NORMAL TESTS BUT PERSISTENT SYMPTOMS? COULD THIS BE LYME-RELATED DYSFUNCTION? Constipation in Lyme disease is common and often misunderstood—especially when diet, hydration, and routine testing appear normal. “I was doing everything right—but nothing was working.” Quick Answer: Constipation in Lyme disease is often

Chronic Lyme vs PTLDS: What’s the Difference and Why It Matters The debate over chronic Lyme vs PTLDS isn’t just about terminology—it’s about whether patients feel validated or dismissed. :contentReference[oaicite:0]{index=0} Many patients use chronic Lyme disease to describe ongoing fatigue, pain, and brain fog. Some clinicians prefer post-treatment Lyme disease syndrome (PTLDS), a term that

Immune Dysregulation in Lyme Disease: Why Symptoms Persist Immune dysregulation in Lyme disease may help explain why symptoms such as fatigue, pain, and cognitive changes can persist—even when tests are normal and initial treatment has been completed. Many patients improve—but do not return fully to baseline. This page explains why. Clinical Insight: Persistent symptoms in