Lyme Science Blog

Immune Dysregulation in Lyme Disease: Why Symptoms Persist Immune dysregulation in Lyme disease may help explain why symptoms such as fatigue, pain, cognitive dysfunction, and sleep disruption can persist—even when tests appear normal and standard treatment has been completed. Many patients improve after Lyme treatment but do not return fully to baseline. Increasingly, research suggests

When Medicine Says There’s Nothing More to Do “Nothing more can be done?” Symptoms may persist despite normal testing. Care should not end when uncertainty begins. What does it really mean when you’re told there is nothing more to do—yet your symptoms continue? I wrote this because I often meet patients who have been told

When Symptoms Are Blamed on Aging, Look Deeper When Symptoms Are Blamed on Aging Symptoms blamed on aging are often accepted without question. A patient noticed a gradual decline in stamina as routine activities became exhausting, sleep no longer felt restorative, and shortness of breath appeared with simple tasks. He assumed it was just getting

Long COVID or Lyme Disease? How to Tell the Difference Long COVID and Lyme disease can look alike Fatigue, brain fog, pain, and sweats may overlap A careful history can change the diagnosis Long COVID or Lyme disease? He wasn’t losing his mind—he was losing time. Each week blurred into the next as fatigue and

Fear of a Herxheimer: Why Delaying Treatment Backfires Fear of a Herxheimer reaction is one of the most common reasons patients delay Lyme treatment. The worry can feel bigger than the disease itself. I remember one patient sitting across from me, struggling to find the words before finally admitting: “I’m scared to treat my Lyme