Could dormancy allow Lyme disease to survive antibiotics?

“Dormancy is a protective state where diverse bacteria including M. tuberculosis, S. aureus, T. pallidum (syphilis), and B. burgdorferi (Lyme Disease) curtail metabolic activity to survive external stresses including antibiotics,” states Mali from the University of Houston in the Journal Bacteriology. [1]

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16-year-old boy with Lyme disease presenting as depression

David, a 16-year-old boy, was initially presumed to suffer from long-standing depression. He exhibited anger, frustration, insomnia, poor appetite, mild weight loss, and passive suicidal ideation. David presented with “long-standing depression, exacerbated recently when he stopped dating a girl after only two weeks because he felt too tired and not smart enough,” according to Fallon and colleagues. [1] “He reported feeling spaced out all the time, as if in a fog.”

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7-year-old girl with Lyme disease presenting as attention deficit disorder

Children are at the greatest risk for developing Lyme disease, with the highest rates of infection occurring in those ages 5 to 9. And out of the more than 300,000 people diagnosed annually in the U.S. with Lyme disease, 25% are children, according to the Centers for Disease Control and Prevention (CDC). This is particularly alarming given that the disease can be difficult to identify in younger patients with symptoms often overlooked or attributed to other medical conditions.

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Stroke as a manifestation of Lyme disease

Strokes should be added to the list of manifestations of Lyme disease based on a 2007 systematic review published in Frontiers in Neurology. [1] The authors identified 88 patients in the literature presenting with cerebrovascular course of Lyme neuroborreliosis (LNB).

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Using dogs to map Lyme disease

Our dogs are catching Lyme disease -- in greater numbers and in a wider geographic region. What does this mean for humans? In mapping the prevalence of the tick-borne illness in canines, researchers hope the data may prove useful in predicting areas where human Lyme disease may become a concern.

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Johns Hopkins’ study supports early identification of Lyme disease patients for re-treatment

Lyme disease patients can suffer for years following antibiotic treatment. According to one study, patients with chronic neurologic Lyme disease were ill for up to 14 years. [1] Patients enrolling in three trials sponsored by the National Institutes of Health were sick an average of 4.7 years respectively. [2,3] Meanwhile, researchers at Johns Hopkins recently identified Lyme disease patients who might benefit from early interventions. [4]

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The risk of pain and fatigue after three weeks of Lyme disease treatment

Researchers at John Hopkins describe the risk of pain and fatigue after three weeks of treatment with doxycycline for an erythema migrans rash. According to the article published in Archives of Clinical Neuropsychology, 23 of 107 patients (21%) had a high fatigue total score and 33 of 107 patients (31%) had a high pain score. Only 5 of 107 patients (5%) had a high depression total score.

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When Lyme disease causes a positive test for mononucleosis

False positive serologies for Lyme disease have been previously reported in patients with acute infectious mononucleosis. However, a recent paper describes two cases in which Lyme disease was misdiagnosed as mono based on false positive serologies for the Epstein-Barr virus (EBV).

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Chronic inflammatory demyelinating polyneuropathy (CIDP) case resolved with antibiotics

Lyme disease has been ruled out in other conditions based on negative serologic tests only to seroconvert to positive serologies on follow-up. [1,2] This was demonstrated in the case of a 41-year-old woman with chronic inflammatory demyelinating polyneuropathy (CIDP), according to Perronne from the Infectious Diseases Unit, University Hospital Raymond Poincaré, APHP, Versailles Saint Quentin University, Garches, France.

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High number of Lyme disease diagnoses through the winter in England

Lyme disease is becoming increasingly common in the UK. In fact, a new study reports a 42% increase in the number of Lyme disease diagnoses in hospitals in England between 2011 and 2015.

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