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Lyme Science Blog

Borrelia spirochete are masters at evading immune system

Mice, guinea pigs, dogs, rabbits and monkeys have long been used to study B. burgdorferi infections. But given that rhesus macaques have been shown to most accurately mimic human infection and response to treatment, Embers and her team inoculated rhesus macaques with B. burgdorferi. “The use of nonhuman primates to model this disease provides the […]

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Case report: Persistent pain and fatigue after treatment for Lyme disease

The patient was concerned she might have Lyme disease because she had repeated exposure to ticks and had reported tick bites in the past. However, “She did not recall a tick bite in the weeks preceding the onset of her illness,” Novak writes in Case Reports in Infectious Diseases. [1] Therefore, the primary care doctor made

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40 years after first case, Lyme disease still a burden for Connecticut

Since 1977, “in spite of all endeavors conducted by the Connecticut Department of Public Health (CTDPH) to control the disease, it [Lyme disease] remains endemic with substantial morbidity rates,” states Mollalo, from the Department of Geography at the University of Florida. Mollalo and his team conducted a retrospective study examining changes in the spatial clusters

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Case report: 46-year-old Canadian man with Bell’s palsy

There are varying presentations of Lyme disease with the two most common symptoms including erythema migrans and arthritis, according to the authors of a case review published in the Canada Communicable Disease Report. [1] But they also point out that “Bell’s palsy is not rare — it has been found in 8.2% of reported cases

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How to test for Lyme disease using a tick

“Xenodiagnosis was positive for B. burgdorferi DNA in a patient with erythema migrans early during therapy and in a patient with PTLDS [post-treatment Lyme disease syndrome],” writes Marques from the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. [1] However, there wasn’t enough evidence to conclude that viable spirochetes were present

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CDC advises doctors to consider Lyme disease in emerging states

The CDC previously recommended treatment for patients living in endemic states. “Fourteen states, all located in the Northeast, mid-Atlantic, and upper Midwest regions, met the criteria for classification as states with high incidence (Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, Virginia, and Wisconsin),” writes Schwartz and

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MS and Lyme disease patients call for more participation in clinical trials

It is clear that more patients need to be involved in research and clinical trials if we are going to advance our understanding of Lyme disease and improve patient care. Only 4 clinical trials, sponsored by the National Institutes of Health (NIH) have included chronically ill Lyme disease patients. These trials were small and typically

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Depression common in Lyme disease patients

Zomer and colleagues found that 1 in 5 Lyme disease patients presenting to the Lyme Center Apeldoorn in the Netherlands between January 2008 and December 2014 were diagnosed with depression and Lyme disease. [1] Depression was identified using the Dutch version of the Beck Depression Inventory II (BDI-II) questionnaire. The BDI-II scale has been used

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Child with Lyme disease presenting as pseudotumor cerebri

Individuals with pseudotumor cerebri have an increased intracranial pressure (pressure around the brain) without a tumor or other cause. The symptoms can include stroke-like headaches, nausea and vomiting. The disease can progress to swelling of the optic disc of the eye and vision loss. [2] “A 6-year-old female presented with a 4-day history of bi-frontal,

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