Signs and symptoms of Lyme disease

signs and symptoms of lyme disease

The broad range of signs and symptoms of Lyme disease and the varying presentations from person to person make diagnosing the disease challenging. Furthermore, Borrelia burgdorferi spirochete are adept at evading the immune system. The bacterium can travel through the bloodstream, burrow into tissue and remain dormant for days, months, or even years before symptoms arise.

While many people associate Lyme disease with manifestations such as Bell’s palsy, the circular Bull’s-eye rash, and flu-like symptoms, Lyme disease can also cause sensory, cognitive, neurologic, and cardiac complications, even in its earliest stage. But, the signs and symptoms of Lyme disease are all too frequently attributed to another medical condition.

Objective signs of Lyme disease include Bell’s palsy, synovitis of the knee, and the presence of a Bull’s-eye or erythema migrans rash. However, most people exhibit a wide range of signs and symptoms of Lyme disease that may come and go and fluctuate in their intensity.

Initially, Bell’s palsy, also known as idiopathic facial nerve palsy, may not be attributed to Lyme disease. But making the connection early is important, since corticosteroids, a common treatment for facial nerve palsy, can be harmful to patients with Lyme disease.

Furthermore, researchers in the UK remind clinicians to consider Lyme disease in children who present with Bell’s palsy. “In areas endemic with Lyme disease, Lyme disease should be considered as the likely cause of facial nerve palsy in children until proven otherwise.”

Wide range of signs and symptoms of Lyme disease

Studies indicate that at least 50% of patients with Lyme disease do not exhibit the classic Bull’s-eye rash. When a rash is present, it can appear anywhere on the body. It does not always appear at the site of the tick bite. The rash usually appears between 3 – 30 days after the tick bite.

A rash due to Lyme disease is typically not itchy or painful. It may fade and then reappear and it can be confused with a spider bite. Atypical rashes can also occur. And when multiple rashes appear on the body, it may be an indication that the Borrelia burgdorferi spirochete has disseminated beyond the tick bite and the disease is in a more advanced stage.

If left untreated, the infection can spread to other parts of the body, including the brain and central nervous system, cardiovascular system, peripheral and autonomic nervous system, along with the muscles and joints, and eyes.

Neurologic and cardiac manifestations

Lyme disease can cause neurological and cardiac symptoms such as meningitis, encephalitis, and carditis. But, more often symptoms include severe and unrelenting fatigue, joint pain (with or without swelling), sore muscles, neck and back pain, headaches, light, sound and temperature sensitivity, sleep disturbance, night sweats, irritability, anxiety, despair, sadness, lightheadedness, crying, poor memory and concentration, stiff neck, numbness, and tingling sensations.

Although rare, Lyme carditis can cause sudden death. The authors of a case series warn, “These two cases highlight the importance of early recognition. And treatment, even if it’s empirical, may save lives.”

Another researcher reports, “The burden of Lyme disease and Lyme carditis in U.S. children’s hospitals has increased in recent years.” The authors identified 189 children diagnosed with Lyme carditis between 2007 and 2013.

Lyme-induced encephalopathy

Lyme disease can trigger encephalopathy in some patients, as well. A Tufts University School of Medicine study reports that 24 of 27 Lyme disease patients presented with a mild encephalopathy, which began 1 month to 14 years after the onset of the disease and was characterized by memory loss, mood changes, and sleep disturbances.

Fallon et al. described pain reported by patients with Lyme encephalopathy as being “similar to those of post-surgery patients,” and their fatigue “was similar to that of patients with multiple sclerosis.”

And another study found that 14% of 86 children with Lyme disease exhibited neurocognitive complications including behavioral changes, forgetfulness, declining school performance, headache or fatigue, and in 2 cases, a partial complex seizures disorder.

Signs and symptoms of Lyme disease may be incorrectly attributed to another illness

Patients are often misdiagnosed with a psychiatric disorder, chronic fatigue syndrome, or fibromyalgia. An incorrect diagnosis and delay in treatment can lead to long-term consequences for Lyme disease patients.

Between 34% and 62% of patients have symptoms that persist long term despite treatment. Another study found that at their six-month follow-up visit, “36% of patients reported new-onset fatigue, 20% widespread pain, and 45% neurocognitive difficulties.”

Postural orthostatic tachycardia syndrome (POTS) is an autonomic dysfunction that can appear years after antibiotic treatment for Lyme disease, resulting in fatigue, cognitive impairment, and orthostatic intolerance such as palpitations, lightheadedness, chest discomfort, and shortness of breath, among others.

Other types of chronic manifestations include Lyme encephalopathy, neurocognitive complications, post-Lyme disease syndrome, neuropsychiatric Lyme disease, sensory neuropathy, and carditis.

Psychiatric symptoms common in Lyme patients

An estimated 1 in 3 patients with chronic neurologic Lyme disease suffer from depression, in addition to fatigue, headaches, poor concentration, lightheadedness, and joint pain, according to one study.

Dr. Robert Bransfield, a New Jersey-based psychiatrist, who specializes in treating tick-borne disease infections, has found that in his practice depression is the most common psychiatric illness associated with late-stage Lyme disease.

All too frequently patients with complex, multisystem illnesses are dismissed by clinicians, their symptoms often attributed to a psychiatric illness simply as “a diagnosis of default,” Bransfield writes.

This attitude can lead to tragic delays in identifying a correct diagnosis and appropriate treatment.

10 Replies to "Signs and symptoms of Lyme disease"

  • Frances Goldberg
    07/07/2021 (8:25 am)

    Physicians are likely to misidentify premature Lyme disease on behalf of flu, and later on, they experience a few non-specific symptoms together with a variety of difficulties with different body organs. This is just a partial listing of Lyme disease symptoms, because there are additional than three hundred signs in the medical glossary implying Lyme disease infection.

  • Margaret
    11/23/2020 (3:17 pm)

    I have chronic cystic Lyme disease that was Di 1 1/2 years ago by my Naturopathic Doctor. Canadian test were negative fir Lyme but tge German test was positive. Since then I have been treated with natural substances and I can report I am starting to feel much better. It has been a long and expensive ride.
    If Canadian test is negative,There is no option of treatment.
    My question is- has anyone had skin problems where the area becomes so sore that only a hot water bottle receives the pain. Usually three or four days later the area comes to a head. I can, using a fingernail, lift very painfully a small carrot like “thing” out and the pain is gone. Until, it starts again. These areas are where I experience a past injury. Burn, blunt force injury from a baseball, vaccines, Epidurals first childbirth and tick bites.
    I have taken pictures of these things and put a few in a small bottle of gin. Just in case anyone ever shows any interest in them.
    This site will not let me post the picture but I would share with anyone interested. Suitable for framing. 😀

    • Dr. Daniel Cameron
      11/23/2020 (6:57 pm)

      There are some individuals with Morgellons.

    • Alicia
      04/02/2023 (6:37 pm)

      I am interested in pictures if still available.

  • Dr. Radha Sinha
    11/03/2020 (5:00 am)

    Well Explain about the Lyme Diseases, You Explained very well. Now a days this diseases is Increases and people get misunderstood by the symptoms. Wrong diagnosis and delay in treatment can lead more consequences for Lyme disease person People must have to connect to the doctors soon if any of the symptom is showing.

  • mary lou hensel
    10/09/2020 (2:08 am)

    I was bitten about 6 weeks ago I reached around my back and smashed t before I realized what it ws. Had blood ov er my fingers. Could not get any of the body. I have been very depressed the last two weeks, but with this quaranteen I thought it was the cause. I am also that as 86 years old. I don’t venture out.much. I contracted lyme 40 years ago and it was awful. Dr Burranscan after many trips from FL to Long Island asked me to come to Colgate Pres hospital for tests and found I had Babesia in the brain, for which he and Dr. Phalen treated me and I have survived with many surgeries to remove organs. It actually ruined my life. I have been handicapped for 40 years.

    • Dr. Daniel Cameron
      10/09/2020 (7:59 am)

      I am glad Dr. Burrascano was able to help. I have patients who don’t forget how difficult it has been. I hope you get your health back. Call my office at 914 666 4665 if you have any questions.

  • Joel
    10/08/2020 (1:17 pm)

    After more than a year on abx for babesia Duncani, my neuroologists is claiming that its really stenosis of the cervical spine that is the root cause of my body wide joint pain and tightness, testicle pain, sfn nephropathy, neck pain, insomnia, sensitivity to noise etc etc. I just feel like giving up, as there is really no way for me to sort this out.

    Is there a way to figure out what is really the cause when the MRI does show stenosis and disk degeneration while at the same time getting positive B. Duncani tests?

    • Dr. Daniel Cameron
      10/08/2020 (2:59 pm)

      That is the challenge in medicine. I also check for other tick borne infections. I have patients that I follow who have disc disease. You could have both issues.

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