What happens to the brain during acute Lyme neuroborreliosis?

A group of researchers from Tulane National Primate Research Center in Louisiana injected live Borrelia spirochete into rhesus monkeys and discovered that inflammation plays a “causal role” in the pathogenesis of acute Lyme neuroborreliosis. Their findings were published recently in The American Journal of Pathology.

Borrelia spirochete are injected into monkeys' brains.

Borrelia spirochete are injected into monkeys’ brains.

Individuals diagnosed with Lyme neuroborreliosis typically suffer from headaches, fatigue, memory loss, learning disabilities, and depression. Clinical findings have included meningitis, cranial neuritis, radiculoneuritis, encephalopathy, encephalitis, encephalomyelitis, radiculitis, radiculoneuritis, mononeuropathies, plexopathies, and demyelinating neuropathies.

Dr. Mario T. Philipp and colleagues at the Tulane National Primate Research Center launched an investigation to examine the role of inflammation on the central nervous system of subjects infected with Borrelia burgdorferi (Bb). Rhesus monkeys were injected with live Bb spirochete. Several monkeys received a potent steroid prior to being injected with the spirochete, while another group was pretreated with a non-steroidal (NSAID) medicine.

The NSAID and control group experienced extensive neurologic damage. The cerebrospinal fluid revealed significantly elevated levels of IL-6, IL-8, chemokine ligand 2, and CXCL13 and pleocytosis in the monkeys, according to a study published in The American Journal of Pathology. Additional pathological changes included:

  1. Leptomeningitis (meningitis)
  2. Vasculitis (inflammation of blood vessels in the brain)
  3. Focal inflammation in the central nervous system
  4. Necrotizing focal myelitis in the cervical spinal cord
  5. Radiculitis (pain that radiates along the nerve due to inflammation on the nerve root at its connection to the spinal column)
  6. Neuritis (inflammation of the nerves)
  7. Demyelination in the spinal roots (erosion of the myelin sheath that normally protects nerve fibers)
  8. Inflammation with neurodegeneration in the dorsal root ganglia (Inflammation and progressive loss of structure or function of neurons in the dorsal root ganglia, or spinal ganglion. The dorsal root ganglion contains the cell bodies of sensory neurons that bring information from the periphery to the spinal cord.)
  9. Neuronal and satellite glial cell apoptosis
  10. Persistent abnormal F-wave chrono dispersions localized to the nerve roots, suggesting damage to axons or demyelination, that were similar to several inflammatory demyelinating peripheral neuropathic disorders, including Guillain-Barré. (Guillain-Barre syndrome is a rare disorder in which your body’s immune system attacks your nerves.)

However, there were no inflammation in the central nervous system of the monkeys that were pretreated with the potent steroid, dexamethasone. 

While the monkey study provides insight into the benefits steroids can play when inflammation is present, it’s also important for clinicians to keep in mind the risks steroids can pose to patients with Lyme disease, as steroids can weaken an already overtaxed immune system.

Clinicians should not prescribe steroids to patients suspected of having Lyme disease, based on this primate study. Unfortunately, pretreatment with the non-steroidal medicine was not effective. Researchers and clinicians must continue to search out ways to control the immune response to Lyme disease without exposing patients to steroids.

 

 

 

 

 


29 Replies to "What happens to the brain during acute Lyme neuroborreliosis?"

  • Carolyn Hamilton
    10/27/2020 (5:22 pm)
    Reply

    Dear doctor Cameron, I was bitten by a black legged pacificus ixodes 9 years ago in the San Francisco Bay area when I went camping in the Santa Cruz mountains. After returning home I was sitting in a chair and felt an unusual tingling and then something rolling down my back I looked on the chair and saw a bloody Engorged tick print I went and looked in the mirror And saw A classic big bright red Bullseye rash. I had worked previously as a medical assistant I had seen one patient in the 8 years I worked for a group of 5 internal medicine doctors 1 patient came in and she had classic Bullseye rash on her calf my senior physician diagnosed immediately As a infected tick bite with Lyme Disease.
    Then prescribed antibiotics for the patient.
    So, I looked in a mirror and saw a huge bright red classic bullseye rash on my back shoulder blade.
    I called the primary care provider on my insurance card and explained that I had a bite/rash and wanted to have it looked at in case it was a Lyme infected tick bite.
    This physician refused to see me.
    I took myself to a large San Francisco hospital emergency department and the physician confirmed that I had an infected tick bite with Lyme Disease.
    Said that I needed antibiotics immediately.
    I was relieved because I remembered how one of my cousins in Utah had an undiagnosed tick bite with Lyme Disease and he had been very ill for 2 years.
    My Aunt called me and was very upset that my cousin had seen over 20 physicians and no diagnosis.
    He had suffered for the 2 years then finally diagnosed with positive Lyme Disease and was treated. This was around 1994.
    He’s fine now.
    So I knew that the faster I started antibiotics was the best thing to do.
    However, even though the physician who confirmed that I had Lyme infected bite and needed antibiotics immediately, he refused to prescribe any antibiotics for me.
    I went 2 years without treatment when I should have been started on antibiotics on day 2 of tick rolling off me.
    I found Dr. Stricker- ILADS right in San Francisco.
    He saw me and was upset that no one had treated me.
    He found two co infections; Rocky Mountain Spotted Fever and Babesia.
    He started me on variety of abx and treated me for 3 years.
    Looking back, I didn’t feel like before the bite- my symptoms started around 2 – 3 weeks in.
    My rash faded in 10 days.
    My last office visit Dr. Stricker said he felt that we had killed off the 2 co infections- because my every 3 month lab work had showed negative 3 x.
    He said However my Lyme numbers were high.
    About 30 days after I saw him last I had been having tooth pain and didn’t know that Borellia caused infected teeth.
    I never mentioned to Dr. S.
    Tooth fractured and was surgically removed, Dr. Stricker set up a full day of iv antibiotics the day before the extraction to cover any extra bacteria.
    Unfortunately, the spirochetes flooded to my brain and left ear.
    I couldn’t hear. Muffled sounds like under water.
    I couldn’t walk straight.
    I couldn’t “think” at all.
    This was 4-? Years ago.
    I felt like my hands were tied, my thinking process gone and just sat.
    Unable to open my mail organize my life and I have always been a super organized person, everyone said I was just like my Dad.
    Then I was driven for my next blood work to see Dr. S. In another month.
    I received a phone call from his front desk person who said that I couldn’t come in until I had a full physical exam.
    REALLY BAD TIMING!
    I explained that I didn’t have a primary care and I couldn’t figure out how to find one.
    I said I REALLY NEED TO SEE DR. S. NOW!
    All fell on deaf ears.
    I spent 3 years and $40,000 seeing a very good LLMD and now of all times I am kicked out?
    Big feelings of betrayal.
    Still upset.
    I had started seeing a Naturopathic LLND along with my Dr. S treatment.
    I wanted to cover every angle.
    So after the toxic smoke from the Sonoma fires my body went full toxicity and I called my LLND.
    He detoxed my body and used antibiotics as well.
    I got better.
    Then he said as far as my brain not working – Plus the fact I survived over 20 brain concussions and contusions as a teenager my brain was attracting-? The bacteria and spirochetes.
    He had been at a conference that was pulsing Ceftriaxone iv.
    We started and in 3 weeks I felt better than ever.
    My LLND noticed a difference in me and his nurse and the office workers all said the same.
    I even felt little pulsation on the left side of my head, as if the Ceftriaxone was killing off the spirochetes.
    Then the office closed for Christmas for 2 weeks.
    I restarted my iv in late January through March-?
    I had problems with the front desk not printing out my superbill so I could submit them to my insurance company who ALWAYS reimbursed me 80%.
    I only have a small amount of ssi and I was required to pay each iv session, although I wasn’t receiving my reimbursements and ran out of money ..
    Long twisted story –
    Although it stopped and started my treatment.
    So, basically I never felt that way I felt after the first 3 weeks of i.v treatment.
    Now with each day, no treatment anywhere, I feel like the worst ever.
    I saw your article about the brain and studies on monkeys.
    I can’t really grasp what I read.
    But I think you understand what I am going through.
    I found a Chiropractor 30 minutes from where I had to move 3 years ago.
    I’m closer to Napa than San Francisco, which added to the reason why I can’t get to my LLND for further treatment.
    The LLMD Chiropractor talked with me for over an hour- no cost, explaining how a Cold Laser works on Lyme Disease.
    It penetrates the Biofilms.
    He explained that abx work when you take them then stop working when you stop.
    My G.I. tract is pretty unhappy now and I have been trying to heal it.
    My biggest concern is that I am getting worse….
    My brain. Now my once perfect athletic trim strong body can’t lift a phone book.
    I don’t want to live like this.
    I need to start a fundraiser to buy a used car to get myself to a LLMD treatment.
    I think the cold laser would be worth a try, what do you think?
    Also, I have become scared to talk to people, not in person … just scared to make a phone call.
    Why is that happening?
    The very nice kind Chiropractor I’m afraid to call.
    He is in Walnut Creek, California
    Chris Tucker.
    I would love to hear your opinion.
    Ceftriaxone iv or Cold Laser.
    I am not “living” any quality of life.
    I am forgetting who I am or who I was before the bite …
    I feel like my case is pretty simple and uncomplicated – like I should be healing easily.
    I just haven’t had a good long go of treatment ever …
    I hope I made sense to you.

    • Dr. Daniel Cameron
      10/27/2020 (7:52 pm)
      Reply

      It is a shame you didn’t get treated earlier. I have patients with similar stories. I would assume you have seen other doctors along the way to rule out other illnesses. I do not have experience with cold laser to help.

      • Carolyn Hamilton
        12/23/2020 (7:37 pm)
        Reply

        Dr. Cameron, no I haven’t seen any other doctors along the way to rule out other illnesses.
        I’m confused as why you would ask, because
        I was perfectly healthy when I went camping 9 years ago when a tick attached to my back unknowingly.
        I didn’t know a thing about Lyme disease with two exceptions; the patient I had seen at work with a classic bullseye rash on her leg, (I never forgot the image of it) – and my cousin who had 2 years of undiagnosed Lyme Disease and his terrible symptoms of pain & extreme fatigue.
        Those two incidents were back in the late 1990’s. At that time the San Francisco Bay area had a lot of what they called “The Yuppie Syndrome” and “Chronic Fatigue”
        My guess is that people were infected with Borellia and didn’t know it. Physicians only recognized Lyme Disease if they saw bright red circles expanding outwards – as the CDC ruled the only way to diagnose Lyme Disease.
        Physicians didn’t know how to treat, test or diagnose unless they saw a Classic bullseye rash – my Bullseye lasted for exactly 10 days.
        So it was a confusing time, especially if a person couldn’t see a bullseye rash before it faded away or if they never had a rash to begin with, as you well know.
        So nine years ago I went camping for a short weekend then came home to San Francisco when the tick detached from my back shoulder blade and rolled down my back.
        I looked & saw an engorged bloody tick on my chair and because of the two earlier lessons I learned about “very basic” Lyme Disease I was able to put it together, although as you said; It WAS extremely unfortunate that the physician who was kind and knowledgeable ~ he knew that the Classic Bullseye Rash that he was looking at on my back was definitely an infected tick bite with Lyme Disease. He confirmed it in the hospital records and the CMA & CDC.
        I asked him multiple times why I wasn’t given the antibiotics that he himself said I needed immediately.
        His only answer was that he “wasn’t allowed to treat patients because he was only a n emergency department physician”.
        No, it makes no sense, he wouldn’t prescribe abx for Strept throat? Ear infections?
        I was so convinced from working in the San Francisco medical community – the best Pediatricians, the best Internal medicine group and the best OB – GYN & Hospitals, Dermatologists, Radiology/sonography and so forth that it never occurred to me that I needed a specialist – especially something I had never heard of: LLMD’S …
        I stayed inside the circle I knew about.
        I was sent to an Infectious Disease Specialist who at month 5 months who had drawn my blood and looked me in my eyes, head pounding, chills that felt like they were coming from my bones, a neck that I couldn’t turn to look left or right and I heard a crushed ice sound, nausea, barely able to get out of bed and all the Borellia, Babesia and Rocky Mountain Spotted Fever symptoms ~ This infectious disease specialist says to me; You don’t have Lyme Disease, your lab test was negative.
        I was beyond anger – I just got up and left.
        I had read about these IDSA physicians, so I understood what was happening.
        How can you look me in the eye when my positive confirmation was downstairs in the same building?
        I saw the tick, I felt it detach and roll down my back.
        I read the symptoms of Lyme and I knew I had it.
        When I found a LLMD in my city and he knew to look for co infections and found the Babesia and Rocky Mountain he treated me for 3 years and said I needed to expect a long hard time to get back because NOBODY ever treated me.
        I did start getting better, I was able to get up and walk although I used to fall from a paralysis of my right leg which I think was from killing off spirochetes.
        Then the tooth extraction changed everything.
        EVERYTHING.
        So do you mean that I should see some type of Lyme specialist?
        My LLMD was setting up a brain SPECT that I never had.
        I guess I am asking you what type of “other” physician should I be seeing?
        My LLND started doing a pulsed iv Ceftriaxone 3 years ago and it really cleared my brain – plus a nagging knee pain that I
        had from an old knee surgery that is now back again after stopping abx & the Ceftriaxone.
        I appreciate your help and I know you from Facebook Lyme.
        You are one of the best …
        So what type of physician do you think I should be seeing?
        Just confused as usual now.
        Thank you!

        • Dr. Daniel Cameron
          12/24/2020 (8:20 am)
          Reply

          I follow my patients who are sick to screen for another illness. I encourage consultation with other specialists to rule out other illnesses.

        • Junayid
          06/29/2021 (4:30 pm)
          Reply

          Have you ever read the following book from Stephen Bruhner(?): “Healing Lyme: Natural Healing of Lyme Borreliosis and the Coinfections Chlamydia and Spotted Fever Rickettsiosis, 2nd Edition”. The writer goes into really interesting and potent therapies for lyme, and the comment reviews on Amazon report very positive effects and full-on remissions from lyme through the therapies suggested in the book.

          Fair warning, the book is a thick read, so you might need someone to go through the information for you and help you to digest it, what with your brain fog being still present. That said, many of the folks said that they could recuperate so much in one month on the protocol that they could study the book themselves(despite having heavy brain fog earlier) and do their own homework. Please check out the book, perhaps it might help you.

          Blessings,
          Junayid

  • Laura
    10/14/2020 (6:22 pm)
    Reply

    Hi,

    I am 44 years old, and had emergency neurosurgery in 2011 for hydrocephalus caused by aqueduct stenosis. I had been experiencing gradually worsening neurological symptoms for years, including severe headaches, visual disturbance and depression. I began experiencing the severe headaches in the years after I recall being bitten as an 11 year old child by a black legged tick in Spain. I developed the bulls eye reaction and high fever. I don’t recall being given more than a couple of days’ medication, presumably an antibiotic. My neurosurgeon explained that my aqueducts had ‘silted’ with scar tissue over many years, causing the hydrocephalus. Could my brain damage have been caused by untreated lymes?

    • Dr. Daniel Cameron
      10/14/2020 (7:08 pm)
      Reply

      It can be difficult to diagnose Lyme disease if the focus on on hydrocephalus.  I would typically add a Lyme disease evaluation as some of my patients suffer from more than one condition.

  • Ellen Chiapperini
    08/19/2020 (1:55 pm)
    Reply

    Dr. Cameron:
    I started January 1,2020 with severe chronic headaches on back, left side of head. After several tests and successful left carotid artery surgery for blockage in March, I began having neurological symptoms: mouth drooping to the right, weak muscle control of tongue, tongue going to left when I was asked to stick it out by neurologist, trouble chewing, and trouble concentrating. Those symptoms began about 10 days after carotid surgery. I have added symptoms in the last 4-6 weeks, of some difficulty swallowing, hoarseness in voice, and increased brain fog and forgetfulness. After a huge battery of tests the only thing positive was Lyme disease which was treated with 3 weeks of doxycycline, but I felt no differently. The neurologist still is trying to find the cause of ongoing symptoms.
    Do you have any insight about Lyme and what is going on with me?

    • Dr. Daniel Cameron
      08/19/2020 (6:58 pm)
      Reply

      I advise my patients to follow with their neurologist. I also advise my patients not to throw in the towel on a tick borne illness so soon. Call my office at 914 666 4665 if you have any questions.

  • ilana drucker
    07/30/2020 (1:49 am)
    Reply

    To what extent is disassociation due to chronic Lyme and/or Bartonella? I have an MRI showing non-specific white matters, a high result for basic myelin protein, postive Bart test, 2 + Lyme bands (39 and 41), and nearly 4 years of mostly psych symptoms, especially disassociation, depression, and panic. I’m receiving SOT treatment next week.

    • Dr. Daniel Cameron
      07/30/2020 (7:55 am)
      Reply

      I assume you are referring to Supportive oligonucleotide technique (SOT) -a treatment that uses the messenger RNA to influence the genes in the Lyme or viral infection. I don’t have enough experience to address SOT. Basic myelin protein has been seen in other disorders e.g., multiple sclerosis. I have seen Lyme disease patients with dissociative symptoms. I have seen Lyme disease patients with a range of neuropsychiatric problems.

  • Jan
    06/16/2020 (7:37 am)
    Reply

    Can you be diagnosed with brain and it be a mistake and be Lyme disease

    • Dr. Daniel Cameron
      06/16/2020 (8:34 am)
      Reply

      Lyme disease can be confused with other neurologic diseases.

  • Evan
    06/07/2020 (4:52 pm)
    Reply

    How does Borrelia cause neuronal apoptosis? Is it by drilling into neurons and destroying them from the inside?

  • Marilyn Belanger
    06/05/2020 (9:16 pm)
    Reply

    I have had Lyme for 4.5 yr. I take vitamins and minerals plus curcumin and glucosamine for arthritis in knees and other joints. I am slowly getting weaker and suffering lack of energy. I have no medical help or advice. What else can I do? I know my brain has changed in many ways. It worries me.

    • Dr. Daniel Cameron
      06/06/2020 (8:57 am)
      Reply

      I typically look a second time whether antibiotics might work. I also refer them to other doctors to rule out other illnesses.

  • Lauren
    05/30/2020 (5:54 pm)
    Reply

    My daughter has to take steroids due to adrenal insufficiency. She had Pseudotumor Cerebri/ intracranial Hypertension with facial palsy. They never tested for Lyme. I had one doctor try to test this it fir us- it showed she was iGm positive yet nothing has been done about this. They don’t believe it can be Lyme because that doesn’t happen in Louisiana.

    • Dr. Daniel Cameron
      05/31/2020 (9:21 am)
      Reply

      I find it important to include a revelation by a doctor experienced in treating Lyme diseases. It is hard to evaluate an IgM Western blot without a positive IgG Western blot. Facial palsy can be seen in Lyme disease. It could turn out to two conditions.

  • Gerri Hauser
    01/20/2020 (9:29 am)
    Reply

    Is it possible for a patient diagnosed with parkinsons to have had undiagnosed lyme disease as the causative agent..is there any evidence of lyme disease causing a decrease in the production of dopamine …

    • Dr. Daniel Cameron
      01/20/2020 (1:18 pm)
      Reply

      It is typically difficult to determine the cause of Parkinson’s disease. I have looked at Lyme disease in some Parkinson’s disease. Some of them have improved but they may have suffered from both conditions. I have not reviewed the literature on whether Lyme disease affects dopamine.

  • Dale Ryan
    01/16/2020 (7:53 am)
    Reply

    are there any studies on the effect of tick paralysis from a female pregnant tick. My son was paralysed by such a tick came close to death and years later still has problems with brain function

    • Dr. Daniel Cameron
      01/16/2020 (8:49 am)
      Reply

      There have been a shortage of studies to address your question. I typically send my patients for a neurologic workup and look a second time to determine if there might be an unresolved tick-borne infection

  • Michaela
    11/27/2019 (12:27 pm)
    Reply

    Very interesting. So, what you are saying is that those with chronic inflammation (such as stressed caged animals and most humans) are affected by borreliosis, but those who are are healthy are not. I have six species of borrelia and have had severe lyme borreliosis which also turned out to be a spiritual awakening. I am managing my lyme with natural medicines, and feel fantastic. I would never want to take antibiotics. I see this disease as a symbiotic bacterial upgrade.

    • Rose Scaccia
      01/16/2020 (7:16 am)
      Reply

      What is your holistic treatment plan you are using?

  • Marian Larkin
    01/13/2019 (4:01 pm)
    Reply

    Dr Cameron, Thank you for your major contribution to Lyme disease care and cures Question: Can specific symptoms be attributed to Babesia. And can other symptoms be specific to Lyme and others to Bartonella, etc? Let’s say one has all 3 diseases. Can the patient and doctor sort them out, differentiate? One needs to know which symptom is from which disease to evaluate one’s progress. Thank you.

    • Dr. Daniel Cameron
      01/13/2019 (10:33 pm)
      Reply

      I find it difficult to tease out which symptom goes with which disease. The patients described in studies may suffer from more than one tick borne infection.

  • Colleen
    05/25/2018 (2:49 am)
    Reply

    This discusses pretreatment.
    It doesn’t not discuss post infection treatment.
    So unless someone is being treated with a steroid prior to being infected, (and was it immediately before infecting the primates?) I don’t see how this study does us any good?
    If this were to say they we’re infected and immediately given the steroid or non steroid then it may play a role.
    I do know some who are being treated with steroids post infection and seem to be holding up but when the dose is reduced they tank.

    • Dr. Daniel Cameron
      05/26/2018 (11:31 am)
      Reply

      Agreed, the steroids only worked in an animal model if given before an experimental infection. The article does highlight the potential disease process.

  • Barbara Brady
    05/18/2017 (2:18 am)
    Reply

    I have suffered over 30 years with lyme and several co-infections. My dr forgot to tell me for 18 years because he overlooked the labs. Well, needless to say l have suffered greatly, chronic joint pain, headaches, memory loss, dyslexic thought process and more. I hope and pray research continued and a cure can be found. Thanks to all the tiredless doctors, nurses, lab tech and research persons for their dedicated service to help victims of Lyme.


Join the Lyme Conversation
(Note: comments are moderated. You will see your comment after it has been reviewed.)

Some html is OK