Lyme Science Blog

by Daniel J. Cameron, MD MPH Lantos and colleagues from Duke University Medical Center recently questioned the accuracy of the IgM immunoblot for Lyme disease (LD) in children and adolescents by reviewing a series of patients admitted to Boston Children’s Hospital during a 7-year period. The study, False Positive Lyme Disease IgM Immunoblots in Children, […]

by Daniel J. Cameron, MD MPH In a study entitled “A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library,” Feng and colleagues hypothesize that when Borrelia burgdorferi, the Lyme bacterium, is confronted with certain stressors, such as starvation or exposure to antibiotics,

by Daniel J. Cameron, MD MPH The study focuses on the similarities and differences in male and female Lyme disease patients. However, the authors give little attention to the fact that both the male and female participants suffered from Post-Treatment Lyme Disease Syndrome a decade after treatment. A growing number of studies describe individuals sick

by Daniel J. Cameron, MD MPH As early as 1990, Logigian and colleagues hypothesized that a two-week course of intravenous ceftriaxone would not successfully eradicate the Lyme bacterium. “The likely reason for relapse is failure to eradicate the spirochete completely with a two-week course of intravenous ceftriaxone therapy.” [3] A recently published clinical trial from

According to Rolling Stone, doctors believed the 79-year-old singer’s “increasingly debilitating memory loss was due to either Alzheimer’s or to dementia brought on by blows to the head from the boxing, football and rugby of his teens and early twenties.” He reportedly could not remember what he was doing from one moment to the next,

by Daniel J. Cameron, MD MPH Altmetrics are metrics and qualitative data that are complementary to traditional, citation-based metrics that track and demonstrate the reach and influence of research publications to key stakeholders. [1] The Altmetrics score “can signal that research is changing a field of study, the public’s health, or having any other number of

by Daniel J. Cameron, MD MPH In the article, Randomized Trial of Longer-term Antibiotic Therapy for Symptoms Attributed to Lyme Disease, the authors “assessed whether longer-term antibiotic treatment of persistent symptoms attributed to Lyme disease leads to better outcomes than does shorter-term treatment.” They report that “longer-term antibiotic treatment did not have additional beneficial effects

by Daniel J. Cameron, MD MPH “Multiple trials have shown efficacy for a 10-day course of oral doxycycline for treatment of erythema migrans and for a 14-day course for treatment of early neurologic Lyme disease in ambulatory patients,” the review concludes. Furthermore, “Evidence indicates that a 10-day course of oral doxycycline is effective for HGA

by Daniel J. Cameron, MD MPH The Journal of Vector Ecology was talking about deer keds seen below (family Hippoboscidae, genus Lipoptena), not deer flies (family Tabanidae, genus Chrysops). Thomas Mather pointed out a fun blog about this “tick with wings” at https://www.tickencounter.org/tick_notes/tick_notes_deer_keds#top 2. The Anaplasma phagocytophilum identified in the paper has not been identified

by Daniel J. Cameron, MD MPH In the recent Clinical Infectious Diseases article entitled “Long-term follow-up of patients with Lyme disease: Longitudinal analysis of clinical and quality of life measures,” the authors conclude that “both mental health and physical health scores increased to be at or above national average over time, regardless of Lyme disease